PMID: 7539521Jun 1, 1995Paper

Microbial mutagenic effects of the DNA minor groove binder pibenzimol (Hoechst 33258) and a series of mustard analogues

Mutation Research
L R Ferguson, W A Denny

Abstract

A series of aniline mustards and half-mustards targeted to DNA by linkage (through a polymethylene chain) to the bisbenzimidazole chromophore of pibenzimol (Hoechst 33258) have been evaluated for their mutagenic properties, as estimated in three strains of Salmonella typhimurium, and for their mitotic crossing-over and petite mutagenesis activities in Saccharomyces cerevisiae strain D5. Agarose gel electrophoresis studies showed that only the derivative with the longest linker chain cross-linked DNA, with the remaining compounds being monoalkylators. The parent (non-alkylator) minor groove binding ligand (Hoechst 33258) was inactive in the bacterial strains TA98 or TA100 but weakly mutagenic in TA102, and caused neither mitotic crossing-over nor 'petite' mutagenesis in yeast. Aniline half-mustard itself (monoalkylator) was an effective base-pair substitution mutagen (events in S. typhimurium strain TA100) with some frameshift mutagenesis activity in TA98, but showed only weak effects in the yeast assays, whereas aniline mustard (cross-linker) was inactive in these bacterial systems but caused substantial amounts of mitotic crossing-over in yeast. The composite molecules studied here showed effects more characteristic of the min...Continue Reading

References

Jan 1, 1990·Environmental and Molecular Mutagenesis·M J HorsfallB W Glickman
Sep 20, 1987·Journal of Molecular Biology·P E PjuraR E Dickerson
Dec 1, 1989·Current Opinion in Oncology·M J Lind, N Thatcher
Apr 1, 1989·Journal of Medicinal Chemistry·F M ArcamoneN Mongelli
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Citations

Aug 17, 1996·Mutation Research·P R Turner, W A Denny
May 18, 2007·Mutation Research·Stephanie M NelsonWilliam A Denny
Sep 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sylvia FongRobert J Debs
Oct 4, 2011·Human Nature : an Interdisciplinary Biosocial Perspective·Alice Dreger
Oct 4, 2019·Scientific Reports·Jordan ChamberlinDev P Arya
Feb 8, 2014·Oncotarget·Kirill I KirsanovAlexei V Tulin
Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brian M CawrseKatherine L Seley-Radtke
Dec 2, 1999·Pharmacology & Therapeutics·B S ReddyJ W Lown

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