Microbial networking in cancer: when two toxins collide

British Journal of Cancer
Sarah Tomkovich, Christian Jobin

Abstract

A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+ Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse models, these two bacteria and their corresponding toxins work synergistically to promote colon cancer.

References

Mar 26, 2004·Nature Reviews. Microbiology·Luanne Hall-StoodleyPaul Stoodley
Jul 8, 2005·Journal of Clinical Microbiology·Alexander SwidsinskiHerbert Lochs
Aug 21, 2012·Science·Janelle C ArthurChristian Jobin
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christine M DejeaCynthia L Sears
Nov 7, 2015·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Marta Borges-CanhaPedro Pimentel-Nunes
Jan 4, 2017·Nature Reviews. Microbiology·Aurélie GagnaireJean-Pierre Gorvel
Oct 11, 2017·Gut·Burkhardt FlemerPaul W O'Toole
Dec 26, 2017·Cell Host & Microbe·Bjoern O SchroederFredrik Bäckhed

❮ Previous
Next ❯

Citations

Sep 19, 2019·Journal of Periodontal Research·Irene Lafuente Ibáñez de MendozaJosé Manuel Aguirre Urizar
Apr 4, 2021·Biomedicines·Ali MohamedIrina V Pinchuk
Jun 3, 2021·Toxins·Michael W Dougherty, Christian Jobin

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resections
laser capture microdissection
biopsies

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Related Papers

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
M ItoT Noda
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
Hideki Ishikawa
JBR-BTR : Organe De La Société Royale Belge De Radiologie (SRBR) = Orgaan Van De Koninklijke Belgische Vereniging Voor Radiologie (KBVR)
K BoerenD Perdieus
© 2022 Meta ULC. All rights reserved