Microbial pathogen primary sequence inversely correlates with blood group antigen immunogenicity

Transfusion
Ian BaineChristopher A Tormey

Abstract

It is well known that specific groups of patients immunologically respond more readily than others to red blood cell (RBC) antigens. While allogeneic RBC antigen exposure is the primary determinant of alloantibody formation, other variables are also involved. Given the significant primary sequence identity between common RBC and microbial antigens, we hypothesized that certain individuals may be immunologically primed to form RBC alloantibodies via environmental exposure to cross-reactive microbial epitopes, and that such a correlation may be linked to blood group antigen immunogenicity. We examined the relationship between RBC-microbe peptide homology and the formation of alloantibodies to the most immunogenic RBC antigens, using the BLASTp homology database. Thirteen-residue peptides centered on the polymorphic amino acids of K, Jka , Lua , E, c, M, C, and S antigens were queried for identity with microbial peptides using the BLASTp database. Results were restricted to bacteria and fungi, with a selective threshold of >80% identity for inclusion, to allow for minor peptide variability. Significant peptide identity was found between RBC antigens and pathogenic organisms including B. fragilis, P. aeruginosa, and Candida spp., a...Continue Reading

References

Jul 1, 1969·The Journal of Clinical Investigation·G F Springer, R E Horton
Aug 1, 1970·Vox Sanguinis·J Harrison
Nov 10, 2005·Journal of Autoimmunity·Jean-François Bach
Feb 20, 2009·Autoimmunity Reviews·Jean Pierre Schatzmann PeronLuiz Vicente Rizzo
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyung LeeSarkis K Mazmanian
Sep 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jerry M WellsPeter van Baarlen
Apr 15, 2011·Immunological Reviews·Howard L WeinerHenry Wu
Nov 19, 2011·Clinical Reviews in Allergy & Immunology·Matthew F CusickRobert S Fujinami
Sep 13, 2013·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hideru Togashi
Sep 10, 2014·Current Allergy and Asthma Reports·David C Jay, Kari C Nadeau
Oct 13, 2015·British Journal of Haematology·Alex B RyderChristopher A Tormey
Jun 25, 2016·British Journal of Haematology·Gary Stack, Christopher A Tormey
Oct 18, 2016·Current Opinion in Hematology·Jeanne E HendricksonChristopher A Tormey
Nov 1, 2016·Nature Reviews. Immunology·Wong YuKari C Nadeau
Dec 4, 2016·Hematology·James C Zimring, Krystalyn E Hudson
Apr 20, 2017·Immunity·Yasmine Belkaid, Oliver J Harrison
Jun 10, 2017·Frontiers in Pediatrics·Nelly AmenyogbeRym Ben-Othman
Jun 13, 2017·Nature Reviews. Immunology·Iliyan D Iliev, Irina Leonardi
Jun 22, 2017·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hadi GoubranThierry Burnouf

❮ Previous
Next ❯

Citations

Jul 22, 2021·Transfusion·Yoshiko TamaiUNKNOWN Pediatric RBC Alloimmunization Consortium

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.