Microbial Production of Conjugated Linoleic Acid and Conjugated Linolenic Acid Relies on a Multienzymatic System

Microbiology and Molecular Biology Reviews : MMBR
Ana S SalsinhaLuis M Rodríguez-Alcalá

Abstract

Conjugated linoleic acids (CLAs) and conjugated linolenic acids (CLNAs) have gained significant attention due to their anticarcinogenic and lipid/energy metabolism-modulatory effects. However, their concentration in foodstuffs is insufficient for any therapeutic application to be implemented. From a biotechnological standpoint, microbial production of these conjugated fatty acids (CFAs) has been explored as an alternative, and strains of the genera Propionibacterium, Lactobacillus, and Bifidobacterium have shown promising producing capacities. Current screening research works are generally based on direct analytical determination of production capacity (e.g., trial and error), representing an important bottleneck in these studies. This review aims to summarize the available information regarding identified genes and proteins involved in CLA/CLNA production by these groups of bacteria and, consequently, the possible enzymatic reactions behind such metabolic processes. Linoleate isomerase (LAI) was the first enzyme to be described to be involved in the microbiological transformation of linoleic acids (LAs) and linolenic acids (LNAs) into CFA isomers. Thus, the availability of lai gene sequences has allowed the development of gene...Continue Reading

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Citations

May 30, 2020·Animals : an Open Access Journal From MDPI·Robert BodkowskiRoman Niedziółka
Oct 9, 2020·Journal of Applied Microbiology·M VahvaselkäB Yang
Oct 23, 2019·Biotechnology Advances·Mengyue GongXingguo Wang
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Rounak ChourasiaAmit Kumar Rai

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