Microbial production of organic acids: expanding the markets

Trends in Biotechnology
Michael SauerPaola Branduardi

Abstract

Microbial production of organic acids is a promising approach for obtaining building-block chemicals from renewable carbon sources. Although some acids have been produced for some time and in-depth knowledge of these microbial production processes has been gained, further microbial production processes seem to be feasible, but large-scale production has not yet been possible. Citric, lactic and succinic acid production exemplify three processes in different stages of industrial development. Although the questions being addressed by current research on these processes are diverging, a comparison is helpful for understanding microbial organic acid production in general. In this article, through analysis of the current advances in production of these acids, we present guidelines for future developments in this fast-moving field.

References

Feb 26, 2000·Enzyme and Microbial Technology·K Hofvendahl, B Hahn-Hägerdal
Jun 5, 2002·FEMS Microbiology Letters·Martin GallmetzerWolfgang Burgstaller
Jun 29, 2002·Nature Biotechnology·Ranjan PatnaikStephen del Cardayré
Apr 17, 2003·Applied Microbiology and Biotechnology·Levente Karaffa, Christian P Kubicek
Mar 31, 2004·Bioresource Technology·Haq Ikram-UlJaved Iqbal
Apr 22, 2004·Journal of Biotechnology·A Crolla, K J Kennedy
Oct 7, 2004·Macromolecular Bioscience·Rafael AurasSusan Selke
Oct 20, 2004·Metabolic Engineering·Antonius J A van MarisJack T Pronk
May 5, 2005·Applied and Environmental Microbiology·Satoshi SaitohHaruo Takahashi
Nov 5, 2005·Applied and Environmental Microbiology·Maria PapagianniMichael Mattey
Dec 1, 2005·Applied Microbiology and Biotechnology·L H GrimmD C Hempel
Jan 28, 2006·Science·Arthur J RagauskasTimothy Tschaplinski
Mar 7, 2006·Applied and Environmental Microbiology·Sang Jun LeeSang Yup Lee
Mar 11, 2006·Applied Microbiology and Biotechnology·Ronald H W MaasRuud A Weusthuis
Mar 21, 2006·Bioresource Technology·Yumiko Ohkouchi, Yuzo Inoue
May 24, 2006·Bioscience, Biotechnology, and Biochemistry·Nobuhiro IshidaHaruo Takahashi
Aug 4, 2006·Applied and Environmental Microbiology·Minoska ValliDiethard Mattanovich
Oct 7, 2006·Applied Microbiology and Biotechnology·P S PanesarM R Kosseva
Oct 31, 2006·Applied and Environmental Microbiology·Marja IlménMerja Penttilä
Nov 23, 2006·Biotechnology Letters·Matic Legisa, Michael Mattey
Dec 1, 2006·Biotechnology Journal·Joachim Venus
Dec 19, 2006·Bioresource Technology·Wei LiaoShulin Chen
Jan 2, 2007·Journal of Biotechnology·Alexander KernAnton Glieder
Jan 17, 2007·Applied Microbiology and Biotechnology·Rojan P JohnAshok Pandey
Jan 20, 2007·Trends in Biotechnology·Rajni Hatti-KaulPål Börjesson
Feb 10, 2007·Journal of Agricultural and Food Chemistry·Apostolis A KoutinasColin Webb
Feb 17, 2007·Journal of Basic Microbiology·Rojan Pappy JohnAshok Pandey
Feb 24, 2007·Journal of Industrial Microbiology & Biotechnology·Sarote SirisansaneeyakulYusuf Chisti
Apr 21, 2007·Applied Microbiology and Biotechnology·André FörsterGerold Barth
May 29, 2007·Bioresource Technology·Yu-Peng LiuLei-Lei Zhu
Jun 5, 2007·Biotechnology and Bioengineering·Isabelle Meynial-SallesPhilippe Soucaille
Jul 27, 2007·Applied Microbiology and Biotechnology·Chenyu DuColin Webb
Nov 1, 2007·PloS One·Paola BranduardiDanilo Porro

❮ Previous
Next ❯

Citations

Jan 29, 2014·Applied Biochemistry and Biotechnology·Ratul Kumar Das, Satinder Kaur Brar
Mar 12, 2013·Biotechnology Advances·Vinod KumarSunghoon Park
Apr 10, 2014·TheScientificWorldJournal·F A G GonçalvesJ A Takahashi
Feb 18, 2014·Applied Microbiology and Biotechnology·Svetlana V KamzolovaIgor G Morgunov
Jan 15, 2014·Applied Microbiology and Biotechnology·Frank SonntagJens Schrader
Jun 28, 2014·Applied Microbiology and Biotechnology·Anders G SandströmMarie F Gorwa-Grauslund
Apr 23, 2014·Biotechnology Advances·Camilo S López-Garzón, Adrie J J Straathof
Jun 29, 2014·Applied Microbiology and Biotechnology·Svetlana V KamzolovaIgor G Morgunov
Feb 27, 2010·Microbial Cell Factories·Thore Rohwerder, Roland H Müller
Apr 16, 2010·Applied Microbiology and Biotechnology·Qun RenManfred Zinn
Oct 20, 2010·Omics : a Journal of Integrative Biology·Nuno P MiraIsabel Sá-Correia
Aug 2, 2011·Applied and Environmental Microbiology·Birgitta E EbertAndreas Schmid
Jul 3, 2013·Microbial Cell Factories·Martin Dragosits, Diethard Mattanovich
Sep 17, 2013·Applied and Environmental Microbiology·Stefan ZdraljevicC Gustavo Pesce
Sep 12, 2012·Microbial Cell Factories·Michael SauerDiethard Mattanovich
Nov 19, 2009·Bioprocess and Biosystems Engineering·Christian AnderssonUlrika Rova
Jul 24, 2010·Bioprocess and Biosystems Engineering·M T A P KresnowatiX D Chen
Jun 18, 2010·Journal of Industrial Microbiology & Biotechnology·Yang GuoXinlei Wang
Oct 1, 2010·Journal of Industrial Microbiology & Biotechnology·Elcio Ribeiro Borges, Nei Pereira
Jul 9, 2011·Journal of Industrial Microbiology & Biotechnology·Nicola SecchiPasquale Catzeddu
Apr 24, 2013·Journal of Industrial Microbiology & Biotechnology·Rasmus AgrenJens Nielsen
Sep 9, 2008·Applied Microbiology and Biotechnology·Shohei OkinoHideaki Yukawa
Oct 14, 2008·Applied Microbiology and Biotechnology·Martina HolzGerold Barth
Aug 14, 2012·Current Microbiology·Fernanda L S SebastianesDiego Cortes
Jul 14, 2010·Applied Microbiology and Biotechnology·Torben HoefelDirk Weuster-Botz
Dec 3, 2010·Applied Microbiology and Biotechnology·Danilo PorroDiethard Mattanovich
Jan 5, 2011·Applied Microbiology and Biotechnology·He LiuJian Chen
Jun 19, 2012·Applied Microbiology and Biotechnology·Marzena BlumhoffMichael Sauer
Aug 17, 2012·Applied Microbiology and Biotechnology·Jinlei TangXueli Zhang
Aug 9, 2013·Applied Microbiology and Biotechnology·Stephen H BrownAlan Berry
Aug 15, 2013·Applied Microbiology and Biotechnology·Denise PrzybylskiRoland H Müller
Aug 21, 2013·Applied Microbiology and Biotechnology·Igor G MorgunovVladimir A Samoilenko
Jan 20, 2016·Current Opinion in Biotechnology·Thomas J SchwartzJames A Dumesic
Aug 20, 2015·Critical Reviews in Biotechnology·Veeresh Juturu, Jin Chuan Wu
Jul 16, 2014·Critical Reviews in Biotechnology·Zhe ChiZhen-Ming Chi
Jul 16, 2015·Critical Reviews in Biotechnology·Tuomas MehtiöAnu Koivula

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.