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Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Nature

May 18, 2018

Marlies MeiselBana Jabri

Abstract

Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1-7. In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with a net developmen...read more

Mentioned in this Paper

Study
Gnotobiotics
Asymptomatic Diseases
Somatic Mutation
Tlr2 protein, mouse
Il6
Pyridoxamine-phosphate Oxidase Activity
Permeability
Myeloid Cells
Toll-Like Receptor 2
87
9
1
149
Paper Details
References
  • References38
  • Citations15
1234
  • References38
  • Citations15
12

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Related Papers

© 2020 Meta ULC. All rights reserved

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Nature

May 18, 2018

Marlies MeiselBana Jabri

PMID: 29769727

DOI: 10.1038/s41586-018-0125-z

Abstract

Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1-7. In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with a net developmen...read more

Mentioned in this Paper

Study
Gnotobiotics
Asymptomatic Diseases
Somatic Mutation
Tlr2 protein, mouse
Il6
Pyridoxamine-phosphate Oxidase Activity
Permeability
Myeloid Cells
Toll-Like Receptor 2
87
9
1
149

Feeds With Similar Papers

Inflammation & Cancer

Inflammation has been implicated in initiation and progression of tumors, as well as elimination of cancerous cells. Here is the latest research on the role of inflammation in cancer.

Nature eTOC

Nature is the world's leading multidisciplinary science journal. Discover the latest research from Nature here.

Related Papers

BioMed Research International

TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations

BioMed Research InternationalApril 3, 2014
María Hernández-SánchezJesús-María Hernández-Rivas
Paper Details
References
  • References38
  • Citations15
1234
  • References38
  • Citations15
12

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