Microbial Species Coexistence Depends on the Host Environment.

MBio
Peter DeinesThomas C G Bosch

Abstract

Organisms and their resident microbial communities form a complex and mostly stable ecosystem. It is known that the specific composition and abundance of certain bacterial species affect host health and fitness, but the processes that lead to these microbial patterns are unknown. We investigate this by deconstructing the simple microbiome of the freshwater polyp Hydra We contrast the performance of its two main bacterial associates, Curvibacter and Duganella, on germfree hosts with two in vitro environments over time. We show that interactions within the microbiome but also the host environment lead to the observed species frequencies and abundances. More specifically, we find that both microbial species can only stably coexist in the host environment, whereas Duganella outcompetes Curvibacter in both in vitro environments irrespective of initial starting frequencies. While Duganella seems to benefit through secretions of Curvibacter, its competitive effect on Curvibacter depends upon direct contact. The competition might potentially be mitigated through the spatial distribution of the two microbial species on the host, which would explain why both species stably coexist on the host. Interestingly, the relative abundances of bo...Continue Reading

References

Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Aug 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sebastian Fraune, Thomas C G Bosch
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven D Allison, Jennifer B H Martiny
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Mar 5, 2011·Trends in Ecology & Evolution·Joel L SachsMartin M Turcotte
Apr 22, 2011·Nature·Manimozhiyan ArumugamPeer Bork
May 19, 2012·Trends in Microbiology·Robert A Britton, Vincent B Young
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Sep 4, 2012·Nature Reviews. Microbiology·George HajishengallisMichael A Curtis
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Jul 3, 2013·Annual Review of Microbiology·Thomas C G Bosch
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sören FranzenburgSebastian Fraune
Mar 13, 2014·Trends in Microbiology·Afrah ShafquatCurtis Huttenhower
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aleksej ZelezniakKiran Raosaheb Patil
Aug 4, 2015·Journal of the Royal Society, Interface·Xiang-Yi LiArne Traulsen
Oct 1, 2015·Trends in Microbiology·U G Mueller, J L Sachs
Nov 17, 2015·Cell Host & Microbe·Annah S RoligKaren Guillemin
Dec 8, 2015·Cell·Peter T McKenney, Eric G Pamer
Apr 8, 2016·Cell Host & Microbe·Kirstie McLoughlinKevin R Foster
Apr 22, 2016·Nature Communications·Erik S Wright, Kalin H Vetsigian
Jul 28, 2016·Nature Reviews. Microbiology·Carey D NadellKevin R Foster
Jul 28, 2016·PLoS Biology·Travis J WilesRaghuveer Parthasarathy
Aug 23, 2016·Trends in Microbiology·Melanie Ghoul, Sara Mitri
Aug 16, 2017·Nature Ecology & Evolution·Jonathan FriedmanJeff Gore
Sep 1, 2017·Immunological Reviews·Peter DeinesThomas C G Bosch
Sep 28, 2017·Nature Communications·René AugustinThomas C G Bosch
Nov 23, 2017·Scientific Reports·Andrea P Murillo-RinconThomas C G Bosch
Feb 27, 2018·Annals of the New York Academy of Sciences·Valerie J McKenzieReid N Harris
Mar 30, 2018·Frontiers in Microbiology·Tanita WeinNils F Hülter
Apr 11, 2018·Nature Medicine·Jack A GilbertRob Knight
Mar 1, 2019·Life·Daniel Rodríguez Amor, Martina Dal Bello
Aug 17, 2019·Nature Reviews. Microbiology·Angela E Douglas
Jan 30, 2019·BioRxiv : the Preprint Server for Biology·A. Ortiz LopezJeff Gore

❮ Previous
Next ❯

Software Mentioned

Adobe Illustrator
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Microbiology
Peter DeinesThomas C G Bosch
BioRxiv : the Preprint Server for Biology
Peter DeinesThomas C G Bosch
Journal of the Royal Society, Interface
Xiang-Yi LiMichael Sieber
BioRxiv : the Preprint Server for Biology
Xiang-Yi LiMichael Sieber
© 2021 Meta ULC. All rights reserved