Microbial transformations of alpha-santonin

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Athar Ata, Jason A Nachtigall

Abstract

Fungal biotransformations of alpha-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC 10404). Rhizopus stolonifer (ATCC 10404) metabolized compound 1 to afford 3,4-epoxy-alpha-santonin (2) and 4,5-dihydro-alpha-santonin (3) while Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245) and Mucor plumbeus (ATCC 4740) were capable of metabolizing compound 1 to give a reported metabolite, 1,2-dihydro-alpha-santonin (4). The structures of these transformed metabolites were established with the aid of extensive spectroscopic studies. These fungi regiospecifically reduced the carbon-carbon double bond in ring A of alpha-santonin.

Citations

Jul 12, 2012·Journal of Industrial Microbiology & Biotechnology·Bruno Alves RochaFernando Batista Da Costa
Jan 5, 2007·Chemical & Pharmaceutical Bulletin·Athar AtaBilge Sener
Apr 26, 2011·The Journal of Chemical Physics·A K Khitrin
Sep 28, 2006·Natural Product Reports·Quan-Xiang WuZhong-Jian Jia
Jul 28, 2005·Natural Product Reports·Braulio M Fraga

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