PMID: 7081986Apr 1, 1982Paper

Microbial transformations of warfarin: stereoselective reduction by Nocardia corallina and Arthrobacter species

Applied and Environmental Microbiology
P J Davis, J D Rizzo

Abstract

The microbiological metabolism of warfarin was examined as a model of metabolism in higher organisms, including humans, and to determine the chirality of microbial reductases for application in organic synthesis. Nineteen cultures were examined based on their reported abilities to reduce ketonic substrates, and several were shown to catalyze the desired reaction. Nocardia corallina (ATCC 19070) exhibited complete substrate and product stereoselectivity as it reduced S-warfarin to the corresponding S-alcohol. Arthrobacter species (ATCC 19140) exhibited marked substrate and complete product stereoselectivity since S-warfarin, and to a lesser extent R-warfarin, were reduced to the corresponding S-alcohols. These reductions parallel those reported to occur in mammalian species.

Citations

Sep 1, 1991·Medicinal Research Reviews·A M Clark, C D Hufford
Apr 1, 1985·Medicinal Research Reviews·A M ClarkC D Hufford
Jun 1, 1991·Applied Microbiology and Biotechnology·D A GriffithsS G Jezequel
Dec 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J D Rizzo, P J Davis
May 9, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T NaitohT Horie
Oct 1, 1985·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J Davis, L E Guenthner
Jul 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·A J HuttS C Tan
Mar 21, 2019·Pharmacological Reviews·Gerard ClarkeNiall P Hyland

Related Concepts

Arthrobacter
Metabolic Biotransformation
High Pressure Liquid Chromatography Procedure
Micropolyspora
Oxidation-Reduction
Gen-Warfarin

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