Microbial translocation in neonates and infants receiving long-term parenteral nutrition

Archives of Surgery
A PierroD A Lloyd

Abstract

To explore whether episodes of endogenous septicemias due to microbial translocation are clinically relevant in neonates and infants who are receiving long-term parenteral nutrition (PN). Prospective observational cohort study of 2 years. Neonates and infants who underwent surgical procedures and required PN because of gastrointestinal abnormalities. Surveillance cultures of the oropharynx and gut were obtained at the first of PN and thereafter twice each week. These cultures were processed for all microorganisms, except for coagulase-negative staphylococci, in a semiquantitative manner to detect overgrowth. A blood sample was taken for culture from both the central venous line and peripheral vein on clinical indication only. Microbial translocation was diagnosed when the microorganisms that were isolated from the blood sample were also carried in the throat and/or rectum within the 2 weeks preceding the episode of septicemia. Of 94 infants, 10 (11%) experienced 24 episodes of septicemia (ie, 7.3 septicemic episodes per 1000 days of PN). Six infants experienced 15 episodes of microbial translocation due to enteric microorganisms, including Escherichia coli, Klebsiella, Candida species, and enterococci. Microbial translocation o...Continue Reading

Citations

Jan 10, 2014·Pediatric Research·Mark R Frey, D Brent Polk
Jul 27, 2001·Current Gastroenterology Reports·J P Fryer
Apr 19, 2003·Pediatric Surgery International·S J SinghD Cass
Nov 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas R ZieglerAndrew T Gewirtz
Dec 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Junqiang TianThomas R Ziegler
Aug 31, 2012·International Journal of Microbiology·Paola PapoffCorrado Moretti
Jul 13, 2011·Pediatric Surgery International·Inaki EizaguirreJose María García Arenzxana
Dec 25, 2003·The Proceedings of the Nutrition Society·Simon Eaton
Oct 30, 1998·The Proceedings of the Nutrition Society·S C DonnellD A Lloyd
Dec 21, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Hirozumi SanoKunihiko Kobayashi
Nov 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karim C El KasmiRonald J Sokol
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L GentonJ Schrenzel
Mar 11, 2003·Annual Review of Nutrition·Thomas R ZieglerDean P Jones
Oct 11, 2016·Physics of Life Reviews·Marko JusupTin Klanjšček
Jul 27, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Priscila Castro Cordeiro FernandesDenise von Dolinger de Brito
Feb 14, 2006·Gastroenterology·Jonathan P Fryer, Kishore Iyer
Jan 26, 2000·Journal of Pediatric Surgery·C P KimberA Cuschieri
Aug 23, 2001·Inflammatory Bowel Diseases·C Cucino, A Sonnenberg
Jan 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Marcia H MonacoSharon M Donovan
Nov 10, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M Nucci, E Anaissie
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonathan FryerMichael Abecassis
Feb 16, 2005·Current Opinion in Gastroenterology·Jonathan P Fryer
Apr 10, 2008·The Pediatric Infectious Disease Journal·Deena SutterJudith Epstein
Oct 11, 2005·Acta Paediatrica. Supplement·Josef Neu, Liyan Zhang
Apr 18, 2003·European Journal of Clinical Nutrition·H K F van SaeneD A Lloyd
Dec 1, 2001·Pediatric Research·G SteinwenderH H Wenzl
Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Maitreyi Raman, Johane P Allard
Dec 12, 2001·The Pediatric Infectious Disease Journal·L SaimanUNKNOWN National Epidemiology of Mycoses Study Group
Jun 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Sz-Ying C JoJulie E Bines
Jan 17, 2015·World Journal of Gastroenterology : WJG·Teresa ArrigoCarmelo Salpietro
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·L EddeM P Sherman
Feb 4, 2003·Alimentary Pharmacology & Therapeutics·J Goh, C A O'Morain
Feb 13, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Olivier J GouletJeong-Meen Seo
Sep 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ketan KansagraDouglas Burrin

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