Microbial volatile compounds in health and disease conditions.

Journal of Breath Research
Robin Michael Statham Thorn, John Greenman

Abstract

Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic alcohols and ketones), aromatic compounds, nitrogen containing compounds, and volatile sulfur compounds. A diversity of ecological niches exist in the human body which can support a polymicrobial community, with the exact VOC profile of a given anatomical site being dependent on that produced by both the host component and the microbial species present. The detection of VOCs is of interest to various disciplines, hence numerous analytical approaches have been developed to accurately characterize and measure VOCs in the laboratory, often from patient derived samples. Using these technological advancements it is evident that VOCs are indicative of both health and disease states. Many of these techniques are still largely confined to the research laboratory, but it is envisaged that in future bedside 'VOC profiling' will enable rapid characterization of microbial associated disease, providing vital information to health...Continue Reading

Associated Clinical Trials

References

Sep 1, 1978·Clinical and Experimental Dermatology·K T HollandC D Roberts
May 1, 1978·The British Journal of Dermatology·A MasseyW C Noble
Sep 1, 1978·Clinical and Experimental Dermatology·D J Gould, W J Cunliffe
Jan 1, 1978·Archives of Environmental Contamination and Toxicology·L W HallJ Cairns
May 1, 1976·Journal of Clinical Pathology·K D PhillipsA T Willis
Nov 2, 1976·The Journal of Experimental Medicine·K YamazakiL Thomas
Feb 1, 1976·The Journal of Clinical Investigation·S L GorbachA B Onderdonk
Aug 1, 1992·The Journal of Membrane Biology·M R WilliamsS F Webb
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C LubranoF Di Silverio
Nov 1, 1992·Journal of Periodontal Research·P W JohnsonJ Tonzetich
Dec 1, 1992·The British Journal of Surgery·T O'Brien, J Collin
Jan 1, 1991·Medical Microbiology and Immunology·H HänelM Buslau
Aug 1, 1991·Journal of Periodontology·M RosenbergJ Gabbay
Jun 1, 1991·The British Journal of Dermatology·P J RennieK T Holland
Aug 1, 1990·Oral Microbiology and Immunology·S PerssonJ Carlsson
Jul 1, 1990·Nihon saikingaku zasshi. Japanese journal of bacteriology·S Kobayashi
Jun 1, 1990·The British Journal of Dermatology·F KandaO Nakata
Aug 1, 1987·The British Journal of Dermatology·R P AllakerR H Osborne
May 1, 1987·Molecular and Cellular Endocrinology·K Ichikawa, L J DeGroot
Mar 1, 1987·The Journal of Investigative Dermatology·J J LeydenG F Webster
Feb 1, 1987·The Journal of Applied Bacteriology·J MarshallK T Holland
Jan 1, 1988·Annual Review of Microbiology·R R Roth, W D James
Jul 1, 1988·The Journal of Applied Bacteriology·J MarshallE M Gribbon
Aug 1, 1985·The British Journal of Dermatology·R P AllakerJ I Gowers
Aug 1, 1986·The Journal of Investigative Dermatology·K M NordstromJ J Leyden
Mar 1, 1986·Journal of Clinical Microbiology·A E van den BogaardC P Van Boven
May 1, 1985·Infection and Immunity·W E MooreR R Ranney
Apr 1, 1985·The Australasian Journal of Dermatology·A J WoodgyerW Kaplan
Jul 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·T F McNamaraM Lee
May 1, 1974·Journal of Bacteriology·W W Tso, J Adler
Jan 1, 1973·Analytical Biochemistry·K S Bricknell, S M Finegold
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PaulingP Cary
Feb 1, 1970·Journal of Medical Microbiology·D A Somerville
Jan 1, 1969·Scientific American·M J Marples
Mar 1, 1980·Journal of Periodontal Research·J G KostelcJ Tonzetich
Oct 1, 1981·The Journal of Applied Bacteriology·K T HollandW J Cunliffe
Jul 1, 1984·Journal of Dental Research·W Ng, J Tonzetich

❮ Previous
Next ❯

Citations

Nov 28, 2013·Applied Microbiology and Biotechnology·Raju AarthiKrishnan Sankaran
Mar 13, 2014·Trends in Microbiology·Afrah ShafquatCurtis Huttenhower
Nov 18, 2014·Expert Review of Clinical Immunology·Nara Tagiyeva, Aziz Sheikh
Dec 7, 2013·Nucleic Acids Research·Marie Chantal LemfackBirgit Piechulla
Aug 4, 2015·Angewandte Chemie·Yoav Y BrozaHossam Haick
Mar 31, 2015·Frontiers in Plant Science·Chidananda Nagamangala KanchiswamyMassimo E Maffei
Mar 17, 2015·Trends in Biotechnology·Jian Zhen OuKourosh Kalantar-zadeh
Dec 7, 2013·Chemical Society Reviews·Hossam HaickAnton Amann
Dec 3, 2016·Critical Reviews in Analytical Chemistry·Maciej MilanowskiBogusław Buszewski
May 10, 2018·Journal of Applied Microbiology·M ZareianP Bremer
Jul 26, 2013·Journal of Breath Research·Tsuguyoshi ToyookaYuki Yamada
Feb 26, 2014·Journal of Breath Research·J GreenmanS Nachnani
Apr 3, 2014·Plant, Cell & Environment·J PeñuelasJ P Schnitzler
Dec 28, 2019·Rapid Communications in Mass Spectrometry : RCM·Bhamini VadhwanaGeorge B Hanna
Jan 11, 2017·Journal of Breath Research·Joann PhanKatrine Whiteson
Jan 6, 2015·Journal of Breath Research·Anna SzabóGábor Szabó
Jan 12, 2013·Journal of Breath Research·Jiangjiang ZhuJane E Hill
Sep 14, 2019·Critical Reviews in Analytical Chemistry·Ileana-Andreea RatiuBogusław Buszewski
Oct 23, 2020·Scientific Reports·Shane FitzgeraldAoife Morrin
May 14, 2021·FEMS Microbiology Ecology·Daniela MinerdiRenato Fani

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
bronchoalveolar
lavage

Software Mentioned

Massfinder

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.