Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial

Journal of Periodontology
Hans R PreusVibeke Baelum

Abstract

The benefit of full-mouth disinfection (FDIS) over traditional scaling and root planing (SRP), with or without adjunctive metronidazole, when treating chronic destructive periodontitis remains equivocal, as does the long-term association between clinical and microbiologic outcomes after such strategies. The aim of this study is to examine the relationship between clinical and microbiologic outcomes of four different treatment strategies for chronic destructive periodontitis among patients who maintain excellent oral hygiene and low gingival bleeding scores. One hundred eighty-four patients with periodontitis and capable of maintaining a high standard of oral hygiene were randomly allocated to one of four treatment groups: 1) FDIS + metronidazole; 2) FDIS + placebo; 3) SRP + metronidazole; and 4) SRP + placebo. Recordings of plaque, bleeding on probing, probing depth (PD), and clinical attachment level were carried out in four sites per tooth at baseline, 3 and 12 months after treatment. Before treatment, pooled subgingival samples were obtained from the five deepest pockets, which were sampled again 3 and 12 months after treatment. Microbiologic assessments of eight putative periodontal pathogens were performed using the checke...Continue Reading

Associated Clinical Trials

Aug 31, 2016·Hans Ragnar Preus

References

May 1, 1978·Journal of Clinical Periodontology·P Axelsson, J Lindhe
Sep 1, 1977·Journal of Periodontology·S S Socransky
Feb 1, 1986·The British Journal of Dermatology·Y MiyachiY Niwa
May 1, 1987·Journal of Dental Research·L V MooreR R Ranney
Dec 1, 1995·Journal of Clinical Microbiology·T F FlemmigH Karch
Oct 1, 1996·Journal of Clinical Periodontology·M K HellströmJ Lindhe
Mar 12, 1998·Journal of Clinical Periodontology·S S SocranskyR L Kent
May 16, 2002·Periodontology 2000·Jørgen Slots, Miriam Ting
Apr 3, 2004·Journal of Clinical Periodontology·Renato V AlvesEnilson A Sallum
Jan 25, 2007·Journal of Clinical Periodontology·R P TelesA D Haffajee
Sep 4, 2012·Nature Reviews. Microbiology·George HajishengallisMichael A Curtis

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Citations

Jun 28, 2017·European Journal of Oral Sciences·Hans R PreusJostein I Grytten
Apr 12, 2019·Journal of Clinical Periodontology·Hans R PreusVibeke Baelum
Jun 22, 2018·International Urology and Nephrology·Zekeriya TasdemirIsmail Kocyigit
Dec 28, 2016·Journal of Oral Science·Zekeriya TaşdemirCem A Gürgan

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