Microbiological analysis of a prospective, randomized, double-blind trial comparing moxifloxacin and clindamycin in the treatment of odontogenic infiltrates and abscesses.

Antimicrobial Agents and Chemotherapy
Ingo SobottkaGeorg Cachovan

Abstract

The objective of this study was to identify the oral pathogens found in odontogenic infections, to determine their susceptibilities to amoxicillin-clavulanic acid (AMC), clindamycin (CLI), doxycycline (DOX), levofloxacin (LVX), moxifloxacin (MXF), and penicillin (PEN), and to search for associations between specific pathogens and types of infection. Swabs from patients enrolled in a randomized, double-blind phase II trial comparing MXF with CLI for the treatment of odontogenic abscesses or inflammatory infiltrates were cultured on media for aerobes and anaerobes. All bacterial isolates were identified at the species level. Overall, 205 isolates were cultured from 71 patients: 77 viridans group streptococci, 56 Prevotella spp., 19 Neisseria spp., 17 Streptococcus anginosus group isolates and hemolytic streptococci, 15 other anaerobes, and 21 other bacteria. Ninety-eight percent of pathogens were susceptible to MXF, 96% to AMC, 85% to LVX, 67% to PEN, 60% to CLI, and 50% to DOX. S. anginosus group and hemolytic streptococci were found significantly more frequently (P = 0.04) in patients with abscesses (12/95) than in patients with infiltrates (5/110). In four patients with infiltrates who failed to respond to CLI therapy, three i...Continue Reading

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Citations

Jun 25, 2013·Clinical Oral Investigations·J BolzA W Eckert
Jan 22, 2014·Acta Odontologica Scandinavica·Georg CachovanIngo Sobottka
Nov 4, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C WangF Xue
Jun 6, 2015·Surgical Infections·Rūta RastenienėLinas Zaleckas
Dec 20, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Thomas MückeHerbert Deppe
Dec 3, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroshige MikamoMasahito Nagashima
Sep 27, 2016·The Bulletin of Tokyo Dental College·Masato NaritaKazuyuki Ishihara
May 31, 2020·Clinical Oral Investigations·Nils HeimValentin Wiedemeyer
Mar 2, 2018·Ear, Nose, & Throat Journal·Ann W PlumRonald E Walsh
Jan 23, 2020·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Sang-Hoon Kang, Moon-Key Kim
Nov 1, 2020·Clinical Oral Investigations·Paula I FaggionLeandro Tasso
Apr 30, 2021·Oral Diseases·Ruta RastenieneJolanta Aleksejuniene

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