Microbiological culture methods for pediatric musculoskeletal infection: a guideline for optimal use

The Journal of Bone and Joint Surgery. American Volume
Jarren SectionLawson A B Copley

Abstract

Culture results affect the diagnosis and treatment of children with musculoskeletal infection. To our knowledge, no previous large-scale study has assessed the relative value of culture methods employed during the evaluation of these conditions. The purpose of this study was to identify an optimal culture strategy for pediatric musculoskeletal infection. Children with musculoskeletal infection were retrospectively studied to assess culture results from the infection site or blood; culture type, including aerobic, anaerobic, fungal, and acid-fast bacteria (AFB); antibiotic exposure history; and clinical history of children with positive culture results. We studied 869 children, including 353 with osteomyelitis, 199 with septic arthritis, forty-two with pyomyositis, and 275 with abscess. The 4537 cultures processed included 1303 aerobic, 903 anaerobic, 340 fungal, 289 AFB, and 1702 blood. Of 3004 specimens sent during initial work-up, positive results occurred in 677 of 1049 aerobic cultures (64.5%), 140 of 763 blood cultures (18.3%), eighteen of 722 anaerobic cultures (2.5%), five of 251 fungal cultures (2.0%), and two of 219 AFB cultures (0.9%). Staphylococcus aureus was the most common pathogen isolated, from 428 (50.7%) of 84...Continue Reading

References

Jan 1, 1997·Scandinavian Journal of Rheumatology·R von Essen
Aug 13, 2003·The Pediatric Infectious Disease Journal·Rebecca L Floyed, Russell W Steele
Jan 29, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M L GalluzzoS D Rosenzweig
Jun 27, 2008·Journal of Pediatric Orthopedics·Jesús Saavedra-LozanoOctavio Ramilo
Sep 25, 2008·Journal of Pediatric Orthopedics·Omar A GafurShellye E Crawford
Jan 22, 2009·Rheumatology International·Luciana BredaFrancesco Chiarelli
Feb 25, 2010·Journal of Pediatric Orthopedics·Suraj JoshyMichalis Zenios
Jun 1, 2010·Skeletal Radiology·Anton R WintersteinFrank W Roemer
Sep 16, 2010·The Pediatric Infectious Disease Journal·Heikki PeltolaUNKNOWN Osteomyelitis-Septic Arthritis Study Group
Apr 19, 2013·The Journal of Bone and Joint Surgery. American Volume·Lawson A B CopleyRichard Browne
Jun 12, 2013·Diagnostic Microbiology and Infectious Disease·Kensuke ShojiIsao Miyairi

❮ Previous
Next ❯

Citations

Jul 29, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Alexandre ArkaderKenneth Noonan
Jul 9, 2016·Hand : Official Journal of the American Association for Hand Surgery·Arianna TrionfoRick Tosti
Feb 19, 2016·The Journal of Bone and Joint Surgery. American Volume·Jeffrey E MartusDerek M Kelly
Jun 28, 2017·JBJS Reviews·John F LovejoyIara R A Lacerda
Jun 14, 2017·EFORT Open Reviews·Alexios D Iliadis, Manoj Ramachandran
May 10, 2018·The Pediatric Infectious Disease Journal·John S VorhiesLawson A Copley
Sep 24, 2016·Journal of Pediatric Orthopedics·Michael A BenvenutiJonathan G Schoenecker
Oct 1, 2019·The Journal of Bone and Joint Surgery. American Volume·Alexus M CooperJavad Parvizi
Dec 7, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Robert F MurphyJames F Mooney
Jun 5, 2020·PloS One·Jonathan G Schoenecker, UNKNOWN Children’s Orthopaedic Trauma and Infection Consortium for Evidence Based Study (CORTICES) Group
Feb 26, 2020·Infection and Immunity·Kenneth L Urish, James E Cassat
Jun 11, 2016·Experimental and Therapeutic Medicine·Dan YaoMingguang Wang
Apr 1, 2020·JBJS Reviews·Archana V DharLawson A Copley
Feb 8, 2019·Journal of Pediatric Orthopedics·Michael A BenvenutiJonathan G Schoenecker
Mar 7, 2019·Journal of Children's Orthopaedics·M van der MerweM J Boyle
Oct 3, 2020·JBJS Reviews·Alex L GornitzkyIshaan Swarup
Dec 29, 2020·Infection and Drug Resistance·J Chase McNeil
Mar 4, 2021·The Pediatric Infectious Disease Journal·Deianira PedotoRoberto Della Casa
Aug 13, 2021·BMC Musculoskeletal Disorders·Cheng-He QinChun-Hao Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.