Microbiological epidemiology of preservation fluids in transplanted kidney: a nationwide retrospective observational study

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Alice CorbelCéline Pulcini

Abstract

Kidney transplant recipients are at high-risk for donor-derived infections in the early post-transplant period. Transplant preservation fluid (PF) samples are collected for microbiological analysis. In case of positive PF cultures, the risk for the recipient is unknown and prescribing prophylactic antibiotics is not consensual. This nationwide observational study was aimed to determine the epidemiology of bacterial and fungal agents in kidney transplant PF cultures and identify risk factors associated with positive PF cultures. We performed a retrospective observational study on the following data collected from a national database between October 2015 and December 2016: characteristics of donor, recipient, transplantation, infection in donor, and PF microbiological data. Out of 4,487 kidney transplant procedures including 725 (16.2% 725/4,487) from living-donors, 20.5% had positive PF cultures (living-donors: 1.8% -13/725; deceased-donors: 24.1% - 907/3,762). Polymicrobial contamination was found in 59.9% (485/810) of positive PF cultures. Coagulase-negative staphylococci (65.8% - 533/810) and Enterobacteriaceae (28.0% - 227/810) were the most common microorganisms. Factors associated with an increased risk of positive PF cult...Continue Reading

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Citations

Feb 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Karina O' ConnellKaren Burns

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