Microbiological Persistence in Patients With Mycobacterium avium Complex Lung Disease: The Predictors and the Impact on Radiographic Progression

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Sheng-Wei PanWei-Juin Su

Abstract

Persistent growth of Mycobacterium avium complex (MAC) in the lungs indicates continuous infection in MAC lung disease (MAC-LD), but its clinical significance has not been investigated. We aimed to evaluate the predictors of persistent culture-positivity for MAC (MAC-PP) and its impact on radiographic deterioration in MAC-LD. Patients with MAC-LD at multiple medical centers from 2011 to 2016 were enrolled retrospectively. Microbiological persistence of MAC-LD was defined as MAC-PP exceeding 1 year, in contrast with the negative-conversion group. The outcome was radiographic progression, namely, increased number of involved lung areas or cavitary formation. Among 126 patients with MAC-LD, 75 (60%) were in the MAC-PP group; these patients had a higher proportion of radiographic progression (54%) than patients in the negative-conversion group (odds ratio [OR], 3.318; 95% confidence interval, 1.146-9.612). Independent predictors of MAC-PP were low body mass index (BMI), radiographic nodular-bronchiectatic (NB) pattern, and increase in the highest grade of acid-fast bacilli smear (AFS). Patients with BMI <21 kg/m2, NB pattern, and positive AFS had an OR of 17.7 for MAC-PP, and those with ≥2 of the factors had a 4.5-fold increased OR...Continue Reading

References

May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Sep 16, 2005·Biometrical Journal. Biometrische Zeitschrift·Ronen FlussBenjamin Reiser
Jun 30, 2006·The European Respiratory Journal·S J FowlerD Bilton
Jul 22, 2006·American Journal of Respiratory and Critical Care Medicine·David E GriffithRichard J Wallace
Mar 4, 2011·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Mohammed Al HouqaniTheodore K Marras
Dec 27, 2011·American Journal of Respiratory and Critical Care Medicine·Makoto HayashiYutaka Sugita
Jan 11, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Y ItoM Mishima
Feb 9, 2012·American Journal of Respiratory and Critical Care Medicine·Jennifer AdjemianD Rebecca Prevots
Mar 14, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S KitadaR Maekura
Nov 13, 2012·American Journal of Respiratory and Critical Care Medicine·Marinka KartalijaEdward D Chan
Nov 21, 2013·Annals of the American Thoracic Society·Stacey L MartinianoScott D Sagel
Jun 7, 2014·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S J KimJ H Lee
Jul 26, 2014·Emerging Infectious Diseases·Jung-Yien ChienPo-Ren Hsueh
Aug 19, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiuqin ZhaoYu Pang
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M-R LeeC-J Yu
Mar 11, 2015·Antimicrobial Agents and Chemotherapy·Bo Young LeeKyung-Wook Jo
Apr 4, 2015·American Journal of Respiratory and Critical Care Medicine·Daniel P BoyleChao Qi
Apr 24, 2015·AJR. American Journal of Roentgenology·Anna RozenshteinGregory D N Pearson
Jun 13, 2015·American Journal of Respiratory and Critical Care Medicine·David E GriffithRichard J Wallace
Nov 18, 2016·International Journal of Molecular Sciences·Paola FaverioStefano Aliberti

Citations

Dec 23, 2018·Tuberculosis and Respiratory Diseases·Yong Soo KwonCharles L Daley
Aug 8, 2020·PloS One·Norio KodakaHiroto Matsuse
Sep 3, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Keiji FujiwaraKozo Morimoto
Oct 28, 2020·The Indian Journal of Medical Research·Surendra K Sharma, Vishwanath Upadhyay
May 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Sheng-Wei PanWei-Juin Su
Oct 21, 2020·Chest·David E Griffith, Timothy R Aksamit
Mar 22, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ock-Hwa KimKyung-Wook Jo

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.