Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center

Journal of Ophthalmic Inflammation and Infection
Joanne W HoNatalie A Afshari

Abstract

Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis at a tertiary referral center in the Southeastern USA. This is a retrospective case series of fungal keratitis infections treated at Duke University Eye Center from January 1, 1998, to October 6, 2008. Of the 4651 culture-proven corneal ulcers identified, 63 (1.4 %) were positive for fungal keratitis with a total of 69 fungal organisms isolated. The majority of isolates were filamentous species (44 of 69, 64 %), and the most commonly isolated organism was Curvularia (11 of 69, 16 %). Bacterial coinfections were found in 24 of the 63 cases (38 %). The most commonly associated risk factors were contact lens wear (n = 15, 24 %) and prior penetrating keratoplasty (PKP) (n = 15, 24 %). Twenty-three cases (37 %) required surgical intervention. The rate of surgical intervention was highest in patients with prior PKP (7/15, 47 %). In this study, the leading risk factors for fungal keratitis were contact lens wear and prior PKP. Filamentous species were the most common causative pathogens. A relatively high rate of mixed bacterial-fungal i...Continue Reading

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Citations

Jul 12, 2018·Mycoses·Shahram MahmoudiAli Banafsheafshan
Oct 2, 2019·Vestnik oftalmologii·S N SvetozarskiyS V Shcherbakova
May 14, 2016·Current Opinion in Ophthalmology·Natalie CheungKristin Hammersmith
Jul 28, 2019·International Journal of Molecular Sciences·Ming-Tse KuoHuey-Ling You
Aug 4, 2018·Current Medical Science·Ling-Juan Xu, Li-Xin Xie
Oct 19, 2019·Microbial Pathogenesis·Lingzhi NiuYajuan Zheng
Nov 20, 2020·Clinical Ophthalmology·Ana Maria CunhaJoão Pinheiro-Costa
May 1, 2021·Journal of Fungi·Jeremy J HoffmanAstrid Leck
Sep 25, 2021·Journal of Ophthalmic Inflammation and Infection·Alireza IzadiSadegh Khodavaisy
Nov 19, 2017·Journal français d'ophtalmologie·T BourcierM Sabou

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