Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature

Journal of Periodontology
C M Bollen, M Quirynen

Abstract

The recognition of the microbial origin and the specificity of periodontal infections has resulted in the development of several adjunctive therapies (antibiotics and/or antiseptics) to scaling and root planing in the treatment of chronic adult periodontitis. This article aims to review the "additional" effect of a subgingival irrigation with chlorhexidine, or a local or systemic application of tetracycline or metronidazole, performed in combination with a single course of scaling and root planing in patients with chronic adult periodontitis. All treatment modalities are compared with scaling and root planing, based on their impact on: the probing depth (PD); total number of colony forming units per ml (CFU/ml); the proportions and/or the detection-frequency of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia; and/or on the percentages of cocci, spirochetes, motile, and other micro-organisms on dark field microscopy examination. All treatment modalities, including scaling and root planing without additional chemical therapy, resulted in significant reductions in the probing depth and the proportions of periodontopathogens, at least during the first 8 weeks post-therapy. However in compar...Continue Reading

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Citations

Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luana PerioliCarlo Rossi
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Nov 26, 2002·Journal of Clinical Periodontology·Marc QuirynenDaniel van Steenberghe
May 1, 2008·AAPS PharmSciTech·Luana PerioliCarlo Rossi
Apr 7, 2005·Journal of Clinical Periodontology·Marc QuirynenDaniel van Steenberghe
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