Microbiological/clinical characteristics and validation of topical therapy with kanamycin in aerobic vaginitis: a pilot study

International Journal of Antimicrobial Agents
G TemperaA Cianci

Abstract

The term 'aerobic vaginitis' defines a 'new' vaginal pathology that is neither classifiable as specific vaginitis nor as bacterial vaginosis. We studied a sample of 30 women with a clinical and microbiological diagnosis of aerobic vaginitis and compared the efficacy and tolerability of kanamycin and meclocycline, two products commercially available in Italy in the form of vaginal pessaries. In chronological order of enrollment, the patients were alternately treated with kanamycin or meclocycline; the dose of administration in both groups was of one pessary per day for 6 days. The evaluation of the therapeutic efficacy was carried out both at the first check-up (7th-8th day) and at a second check-up (13th-16th day). At the first follow-up carried out immediately at the end of therapy, the percentage of normalisation of clinical signs and symptoms was increased independently of the type of treatment in the case of moderate grade aerobic vaginitis, while kanamycin was produced a better effect in the group with severe aerobic vaginitis. Furthermore, at the second follow-up, a direct correlation with recovery of vaginal homeostasis was demonstrated by the normalisation of the vaginal pH and by the presence of lactobacilli, only in k...Continue Reading

References

Aug 23, 1985·JAMA : the Journal of the American Medical Association·J SwedbergD A Driggers

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Citations

Sep 28, 2012·Archives of Gynecology and Obstetrics·Aiping FanFengxia Xue
Feb 28, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G S TansarliM E Falagas
Oct 29, 2015·Archives of Gynecology and Obstetrics·Werner MendlingPhilipp Grob
Nov 4, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C WangF Xue
Mar 2, 2016·Taiwanese Journal of Obstetrics & Gynecology·Zhi-Liang WangYong-Hong Zhang
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·Ggg DondersD Rezeberga
Jul 7, 2015·Advanced Drug Delivery Reviews·Rita Palmeira-de-OliveiraJosé Martinez-de-Oliveira
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Apr 22, 2015·Current Infectious Disease Reports·Gilbert G G DondersGert Bellen
Nov 5, 2014·Archives of Gynecology and Obstetrics·Cha HanFengxia Xue
Jul 21, 2016·The Journal of Obstetrics and Gynaecology Research·Qian LiangYing Duan
Nov 24, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Cha HanFengxia Xue
May 16, 2017·Research in Microbiology·Gilbert G G DondersPedro Vieira-Baptista

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