Microbiome analysis reveals gut microbiota alteration in mice with the effect of matrine.

Microbial Pathogenesis
Haigang WuJicheng Liu

Abstract

Mounting evidence revealed the negative effects of abuse of antibiotic including the induction of decreased immunity and dysbacteriosis. Matrine displayed multiple beneficial effects such as anti-inflammatory, antiviral and antibacterial, but studies of its influence on gut microbiota are still insufficient to report. Here, the present study was conducted to investigate the influence of matrine on the gut microbiota of mice and amoxicillin was used as a positive control. A total of 21 cecal samples were obtained from seven groups for high-throughput sequencing analysis based on V3-V4 variable region of 16S rRNA genes. Results revealed that the diversity and abundance of gut microbiota in mice gradually decreased with the increase of the concentration of amoxicillin, whereas matrine administration did not effect the intestinal microbial community structure. Additionally, amoxicillin and matrine supplementation also caused significant changes in the relative abundance of some intestinal bacteria. Specifically, the ratio of Klebsiella and Corynebacterium_1, Bacteroides and Parasutterella in the amoxicillin treated-group were increased as compared to the control group, whereas Muribaculaceae_unclassified, Alistipes and Lactobacillu...Continue Reading

References

Mar 1, 1988·Journal of Clinical Periodontology·A J van WinkelhoffJ de Graaff
May 5, 2000·International Journal of Antimicrobial Agents·A E van den Bogaard, E E Stobberingh
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jul 17, 2008·Journal of Medical Microbiology·Gaetano IapichinoLorenzo Morelli
Nov 4, 2008·Trends in Microbiology·Filip Van ImmerseelRichard W Titball
Mar 28, 2009·The Lancet Infectious Diseases·Patrice NordmannThierry Naas
Mar 23, 2011·Applied Microbiology and Biotechnology·Léa Cabrol, Luc Malhautier
Aug 5, 2011·Diabetes, Obesity & Metabolism·R S KootteM Nieuwdorp
Sep 17, 2011·Frontiers in Microbiology·Michele M KosiewiczPascale Alard
Sep 14, 2012·Nature·Valentina Tremaroli, Fredrik Bäckhed
Sep 19, 2012·The American Journal of Gastroenterology·Laura RigsbeeOleg Paliy
Jan 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Q AzizE M M Quigley
Apr 27, 2013·Nature Reviews. Immunology·Nobuhiko KamadaGabriel Núñez
Jul 3, 2013·Therapeutic Advances in Gastroenterology·Caitriona M Guinane, Paul D Cotter
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Jan 7, 2014·Advances in Immunology·Jian TanLaurence Macia
Sep 28, 2016·Current Biology : CB·Fanli KongJiangchao Zhao
Dec 16, 2016·The New England Journal of Medicine·Susan V Lynch, Oluf Pedersen
Feb 22, 2017·International Journal of Biological Macromolecules·Weijie LvShining Guo
Apr 9, 2017·Journal of Translational Medicine·Rasnik K SinghWilson Liao
May 11, 2018·Journal of Gastroenterology and Hepatology·Yan-Jie ChenXi-Zhong Shen
Aug 1, 2018·European Journal of Pharmacology·Zhongwei LiuYan Guo
Aug 31, 2018·Frontiers in Microbiology·Yu LeiXiaolong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Mei LiuJian-feng Cheng
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine
H R Tan, B H Zhang
© 2021 Meta ULC. All rights reserved