Nov 26, 2015

Microbiome and Gluten

Annals of Nutrition & Metabolism
Yolanda Sanz


Celiac disease (CD) is a frequent chronic inflammatory enteropathy caused by gluten in genetically predisposed individuals that carry disease susceptibility genes (HLA-DQ2/8). These genes are present in about 30-40% of the general population, but only a small percentage of carriers develops CD. Gluten is the key environmental trigger of CD, but its intake does not fully explain disease onset; indeed, an increased number of cases experience gluten intolerance in late adulthood after many years of gluten exposure. Consequently, additional environmental factors seem to be involved in CD. Epidemiological studies indicate that common perinatal and early postnatal factors influence both CD risk and intestinal microbiota structure. Prospective studies in healthy infants at risk of developing CD also reveal that the HLA-DQ genotype, in conjunction with other environmental factors, influences the microbiota composition. Furthermore, CD patients have imbalances in the intestinal microbiota (dysbiosis), which are not fully normalized despite their adherence to a gluten-free diet. Therefore, it is hypothesized that the disease can promote dysbiosis that aggravates CD pathogenesis, and dysbiosis, in turn, can initiate and sustain inflammati...Continue Reading

  • References
  • Citations8


  • We're still populating references for this paper, please check back later.
  • References
  • Citations8


Mentioned in this Paper

Pathogenic Aspects
Informational Intervention
Anti-Inflammatory Agents
Human Leukocyte Antigen DQ (Lab Test)
HLA-DQ2 antigen
Chronic Inflammation

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Clinical & Developmental Immunology
Tamara Pozo-RubioYolanda Sanz
Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
L I Fernández SalazarJ A Garrote Adrados
Gastroenterology and Hepatology From Bed to Bench
Clelia CiceroneStefano Pontone
© 2020 Meta ULC. All rights reserved