Microbiome-intestine cross talk during acute graft-versus-host disease.

Blood
Hind Rafei, Robert R Jenq

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-SCT) offers cure for a variety of conditions, in particular, but not limited to, hematologic malignancies. However, it can be associated with life-threatening complications, including graft-versus-host disease (GVHD) and infections, which are factors limiting its widespread use. Technical advances in the field of microbiome research have allowed for a better understanding of the microbial flora of the human intestine, as well as dissection of their interactions with the host immune system in allo-SCT and posttransplant complications. There is growing evidence that the commensal microbiome is frequently dysregulated following allo-SCT and that this dysbiosis can predispose to adverse clinical outcomes, especially including acute intestinal GVHD and reduced overall survival. In this review, we discuss the interactions between the microbiome and the components of the immune system that play a major role in the pathways leading to the inflammatory state of acute intestinal GVHD. We also discuss the microbiome-centered strategies that have been devised or are actively being investigated to improve the outcomes of allo-SCT patients in regard to acute intestinal GVHD.

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Citations

Oct 2, 2020·Current Opinion in Hematology·Sarah Lindner, Jonathan U Peled
Mar 2, 2021·Current Opinion in Immunology·Muna QayedEdmund K Waller
Mar 2, 2021·Frontiers in Physiology·Zhengcan ZhouYuxin Feng
Mar 19, 2021·Blood·Yi-Bin Chen
Apr 7, 2021·Blood Cancer Journal·Bruce D ChesonGilles Salles
Jun 9, 2021·The Journal of Clinical Investigation·Gérard SociéBruce R Blazar
Aug 10, 2021·Blood·Ronjon Chakraverty, Takanori Teshima

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