Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis

Journal of Endodontics
Jinxin ZhengLigeng Wu

Abstract

This study examined the identity of the microbiome of deep dentinal caries and its correlation with the inflammation status of caries-induced pulpitis. Seventy-five cases were diagnosed based on the American Association of Endodontics's diagnostic criteria and divided into 4 groups: normal pulp with deep caries (NP; n = 13), reversible pulpitis with only cold-evoked pain (CRP; n = 17), reversible pulpitis with both cold/heat-evoked pain (CHRP; n = 24), and symptomatic irreversible pulpitis (SIP; n = 21). Samples were sequenced by 16S rDNA. Alpha and beta diversity were determined. Linear discriminant analysis effect size (LEfSe) analysis was used to detect intergroup differences, and receiver operating characteristic (ROC) curves were generated to assess the role of the caries microbiome in caries-induced pulpitis. The 16S rDNA sequencing yielded 9100 operational taxonomic units. Lactobacillus had the highest relative abundance at the genus level among the 4 groups. There were significant differences in the distribution of the microbiome among the groups. In an alpha diversity analysis, species richness differed between the CRP group and the other groups. In a beta diversity analysis, the distribution of microorganisms in the S...Continue Reading

Citations

Apr 15, 2020·International Journal of Molecular Sciences·Sharmely Sharon Ballon RomeroYi-Hung Chen
Dec 29, 2020·Journal of Endodontics·Shatha ZahranGarrit Koller
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Manuel ToledanoRaquel Osorio
Nov 2, 2019·Cytokine·Mohammad M Y KhorasaniHossein Khorramdelazad
Apr 17, 2020·Journal of Endodontics·Cuicui SunLigeng Wu
Aug 11, 2021·International Endodontic Journal·José Luis Muñoz-CarrilloOscar Gutiérrez-Coronado
Aug 28, 2021·Cells·José Luis Muñoz-CarrilloKarla Karina Díaz-Huerta

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