Microbiome signatures in prostate cancer

Carcinogenesis
Sagarika BanerjeeErle S Robertson

Abstract

We have established a microbiome signature for prostate cancer using an array-based metagenomic and capture-sequencing approach. A diverse microbiome signature (viral, bacterial, fungal and parasitic) was observed in the prostate cancer samples compared with benign prostate hyperplasia controls. Hierarchical clustering analysis identified three distinct prostate cancer-specific microbiome signatures. The three signatures correlated with different grades, stages and scores of the cancer. Thus, microbiome signature analysis potentially provides clinical diagnosis and outcome predictions. The array data were validated by PCR and targeted next-generation sequencing (NGS). Specific NGS data suggested that certain viral genomic sequences were inserted into the host somatic chromosomes of the prostate cancer samples. A randomly selected group of these was validated by direct PCR and sequencing. In addition, PCR validation of Helicobacter showed that Helicobacter cagA sequences integrated within specific chromosomes of prostate tumor cells. The viral and Helicobacter integrations are predicted to affect the expression of several cellular genes associated with oncogenic processes.

References

Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
Apr 16, 1999·The Journal of Hospital Infection·V KrcmeryD W Denning
Aug 2, 2001·Journal of the National Cancer Institute·I Horikawa, J C Barrett
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jenny KimRobert L Modlin
Jul 25, 2003·The New England Journal of Medicine·William G NelsonWilliam B Isaacs
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew P Thompson, Razelle Kurzrock
Oct 4, 2005·Journal of Medical Genetics·D Baralle, M Baralle
Mar 28, 2006·Future Oncology·Beverley A ShannonRonald J Cohen
Apr 22, 2006·Advances in Experimental Medicine and Biology·Nasimul Ahsan, Keerti V Shah
Jan 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hung Fan
May 16, 2007·Molecular Microbiology·John C Carmen, Anthony P Sinai
Nov 16, 2007·Journal of Medical Case Reports·Athanasios ZahariouPolyanthi Papaioannou
Dec 28, 2007·Journal of Virology·Dweepanita DasMichael J Imperiale
Apr 3, 2008·Current Opinion in Urology·Eric A Klein, Robert Silverman
May 22, 2009·Journal of Gastrointestinal Cancer·Angela R LonoTan T Chye
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert SchlabergIla R Singh
Feb 12, 2010·Bioinformatics·Thomas D Wu, Serban Nacu
Apr 27, 2010·Journal of Medical Virology·Harpreet JohalWilliam D Rawlinson
Jun 3, 2010·Nature Reviews. Urology·Robert H SilvermanEric A Klein
Jun 15, 2010·Cancer Epidemiology·Angela Rosa AndréSílvia Helena Barem Rabenhorst
Oct 15, 2010·International Journal of Medical Microbiology : IJMM·Lina Fassi FehriHolger Brüggemann
Oct 26, 2010·Cancer Letters·Ronit Sarid, Shou-Jiang Gao
Jan 29, 2011·The Lancet Infectious Diseases·Marisa H MiceliSamuel A Lee
Mar 15, 2011·Irish Journal of Medical Science·Y LinL Xie
Jan 1, 2010·Frontiers in Microbiology·Kathleen R JonesD Scott Merrell
Jan 4, 2012·Histopathology·Karen S Sfanos, Angelo M De Marzo
Jan 25, 2012·Virchows Archiv : an International Journal of Pathology·Natalie LudygaMichaela Aubele
Apr 21, 2012·Briefings in Bioinformatics·Helga ThorvaldsdóttirJill P Mesirov
May 16, 2012·Cancer Discovery·Christopher L Corless, Paul T Spellman
Aug 2, 2012·Prostate Cancer and Prostatic Diseases·M IanniF Licastro
Jul 11, 2013·PLoS Computational Biology·David R RileyJulie C Dunning Hotopp
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Feb 12, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Teodora RibarskaWolfgang A Schulz
Aug 6, 2014·Singapore Medical Journal·AbdelRahman Mohammad ZueterRahmah Noordin
Sep 27, 2014·Disease Models & Mechanisms·Ye Yang, Christian Jobin

❮ Previous
Next ❯

Citations

Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Sep 22, 2019·Nutrients·Tracey L LivingstoneMaria H Traka
Jul 2, 2020·Frontiers of Medicine·Solmaz Ohadian Moghadam, Seyed Ali Momeni
Sep 5, 2020·Infectious Agents and Cancer·Paul KatongoleNixon Niyonzima
Sep 8, 2019·Current Urology Reports·Karen M Wheeler, Michael A Liss
Jun 18, 2020·Nature Reviews. Cancer·Johann S de BonoAndrea Alimonti
Jun 4, 2020·Genome Biology·Sumeed Syed ManzoorMichael B Burns
Oct 13, 2020·Der Urologe. Ausg. A·G MagistroC G Stief
Dec 31, 2020·Medicinal Research Reviews·Cheng FangXian-Tao Zeng
Nov 6, 2020·Cancer Research·Sheetal Parida, Dipali Sharma
Apr 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rasoul MirzaeiSajad Karampoor
Jun 3, 2021·International Journal of Molecular Sciences·Sana HibinoKoji Taniguchi
Jun 9, 2021·Aktuelle Urologie·Michael AtzlerGiuseppe Magistro
Jun 18, 2021·Frontiers in Microbiology·Holger BrüggemannRolf Lood
Jul 17, 2021·Prostate Cancer and Prostatic Diseases·Juan Javier-DesLogesJ Kellogg Parsons
May 30, 2021·Cancer Science·Makoto MatsushitaNorio Nonomura
Aug 21, 2021·BMC Cancer·Zi-Kun YuPei-Yu Huang
Oct 13, 2021·Annals of the New York Academy of Sciences·Jakub P PiwowarskiSebastian Granica
Dec 2, 2021·Journal of the National Cancer Institute·Daniel DiMaioAmy Justice

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.