Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women

Nutrición hospitalaria
D Linetzky WaitzbergR S Matos de Miranda Torrinhas

Abstract

Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation. This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids. Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d IPHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively. There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046)...Continue Reading

Citations

Feb 28, 2019·Frontiers in Medicine·Toshifumi OhkusaNobuhiro Sato
Apr 10, 2019·Infection and Immunity·Chikako ShimokawaHajime Hisaeda
Oct 21, 2018·Medical Sciences : Open Access Journal·Yurdagül ZopfWalburga Dieterich

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