Microbiota-mediated mucosal inflammation in arthritis.

Best Practice & Research. Clinical Rheumatology
Meagan E Chriswell, Kristine A Kuhn

Abstract

Mucosal surfaces are a unique symbiotic environment between a host and a vast and diverse ecology of microbes. These microbes have great immunomodulatory potential with respect to the host organism. Indeed, the mucosal immune system strikes a delicate balance between tolerance of commensal organisms and overt inflammation to ward off pathogens. Disruptions of the microbial ecology at mucosal surfaces has been described in a vast number of different human disease processes including many forms of arthritis, and the resulting implications are still being understood to their fullest. Herein, we review the current state of knowledge in microbe-host interactions as it relates to the development of arthritis through bacterial translocation, bacterial metabolite production, education of the immune response, and molecular mimicry.

Citations

Dec 1, 2020·Frontiers in Cellular and Infection Microbiology·Paula FridMohammed Al-Haroni
May 25, 2021·The Journal of Pain : Official Journal of the American Pain Society·Emily PayneGlenn W Stevenson

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