Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling

Development
Joshua V TrollKaren Guillemin

Abstract

Resident microbes promote many aspects of host development, although the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted epistasis experiments to establish whether the microbiota modulates host Notch signaling. We also investigated whether innate immune signaling transduces microbiota cues via the Myd88 adaptor protein. We provide the first evidence that microbiota-induced, Myd88-dependent signaling inhibits host Notch signaling in the intestinal epithelium, thereby promoting secretory cell fate determination. These results connect microbiota activity via innate immune signaling to the Notch pathway, which also plays crucial roles in intestinal homeostasis throughout life and when impaired can result in chronic inflammation and cancer.

References

Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guor Mour HerJen-Leih Wu
Jan 18, 2005·Mechanisms of Development·Kenneth N WallaceMichael Pack
Jun 20, 2006·Developmental Biology·Jennifer M BatesKaren Guillemin
Mar 6, 2007·Developmental Biology·Stefan PaulsFrancesco Argenton
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Milena BogunovicScott E Plevy
Dec 19, 2007·European Journal of Immunology·Tanapat PalagaBarbara A Osborne
Nov 15, 2008·Nature Protocols·Linh N PhamJohn F Rawls
Apr 14, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Arbab SikanderKaushal Kishor Prasad
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin DistelReinhard W Köster
Oct 15, 2009·Genome Research·Gemma C LangridgeA Keith Turner
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah E CheesmanKaren Guillemin
Feb 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M VincentH E Raybould
Jan 18, 2012·Handbook of Experimental Pharmacology·Gwen TolhurstFiona M Gribble
Jan 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuuki ObataHiroshi Ohno
Aug 8, 2012·Nature Reviews. Genetics·K G GuruharshaSpyros Artavanis-Tsakonas
Sep 18, 2012·The Biological Bulletin·Michael J TaorminaKaren Guillemin
Nov 3, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julie TomasClaire Cherbuy
Nov 30, 2012·Annual Review of Physiology·Taeko K Noah, Noah F Shroyer
Jan 31, 2013·Development·Ute KochFreddy Radtke
Feb 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Margaret McFall-NgaiJennifer J Wernegreen
Mar 9, 2013·Disease Models & Mechanisms·Michiel van der VaartAnnemarie H Meijer
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Purna C KashyapJustin L Sonnenburg
Sep 2, 2014·Developmental Biology·Danhua ZhangP Duc Si Dong
Oct 27, 2014·Carcinogenesis·Karina PeregrinaLeonard H Augenlicht
Jan 1, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher S ReigstadPurna C Kashyap
Apr 16, 2015·Mucosal Immunology·G M H BirchenoughG C Hansson
Sep 5, 2015·The ISME Journal·W Zac StephensBrendan J M Bohannan
Sep 6, 2015·Cancer Letters·Xun YuanKongming Wu
Oct 8, 2015·Annual Review of Physiology·Fiona M Gribble, Frank Reimann
Feb 18, 2016·Therapeutic Advances in Endocrinology and Metabolism·Ramona PaisFrank Reimann
Jul 28, 2016·PLoS Biology·Travis J WilesRaghuveer Parthasarathy

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Citations

Feb 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Juan F Burgueño, Maria T Abreu
Dec 12, 2018·PLoS Biology·Catherine D RobinsonBrendan J M Bohannan
Mar 3, 2020·Frontiers in Immunology·Adrià López NadalSylvia Brugman
Jun 17, 2020·Lab Animal·Keaton StagamanKaren Guillemin
Oct 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Jennifer K HeppertJohn F Rawls
Sep 25, 2020·Integrative and Comparative Biology·Lucas J KirschmanKathryn C Milligan-Myhre
Jan 29, 2021·World Journal of Gastroenterology : WJG·Xiaoqiang QiGuangfu Li
Dec 2, 2020·Annual Review of Animal Biosciences·Nuno BorgesRodrigo Costa
Dec 1, 2018·Current Colorectal Cancer Reports·Ishfaq Ahmed, Shahid Umar
May 23, 2020·Mechanisms of Development·Katherine B WilliamsMichael Levin
May 13, 2021·The FEBS Journal·Meghan Ferguson, Edan Foley
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Sudha B SinghHenry C Lin
Nov 11, 2021·Development·Lihua Ye, John F Rawls

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