Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer.

Microbiology and Molecular Biology Reviews : MMBR
Matteo BelloneSamuel Huber

Abstract

Technologies allowing genetic sequencing of the human microbiome are opening new realms to discovery. The host microbiota substantially impacts immune responses both in immune-mediated inflammatory diseases (IMIDs) and in tumors affecting tissues beyond skin and mucosae. However, a mechanistic link between host microbiota and cancer or IMIDs has not been well established. Here, we propose T helper 17 (TH17) lymphocytes as the connecting factor between host microbiota and rheumatoid or psoriatic arthritides, multiple sclerosis, breast or ovarian cancer, and multiple myeloma. We theorize that similar mechanisms favor the expansion of gut-borne TH17 cells and their deployment at the site of inflammation in extraborder IMIDs and tumors, where TH17 cells are driving forces. Thus, from a pathogenic standpoint, tumors may share mechanistic routes with IMIDs. A review of similarities and divergences in microbiota-TH17 cell interactions in IMIDs and cancer sheds light on previously ignored pathways in either one of the two groups of pathologies and identifies novel therapeutic avenues.

References

Nov 2, 2002·Blood·Muneo NumasakiMichael T Lotze
May 7, 2003·The Journal of Experimental Medicine·Thomas EnzlerGlenn Dranoff
Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Feb 17, 2007·The Journal of Clinical Investigation·Pier Paolo PiccalugaStefano A Pileri
Jun 22, 2007·The New England Journal of Medicine·Robert A KyleS Vincent Rajkumar
Jul 21, 2007·International Journal of Cancer. Journal International Du Cancer·Dong Hyuk KiSun Young Rha
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Jan 19, 2008·The Journal of Clinical Investigation·Hak-Ling MaDeborah A Young
Mar 21, 2008·Blood·Pawel MuranskiNicholas P Restifo
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Aug 22, 2008·Nature·Koji AtarashiKiyoshi Takeda
Sep 17, 2008·Nature Reviews. Microbiology·Ruth E LeyJeffrey I Gordon
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yoshihiro MiyaharaRong-Fu Wang
Dec 31, 2008·The Journal of Experimental Medicine·Marc VeldhoenBrigitta Stockinger
Jul 1, 2009·The Journal of Experimental Medicine·Lin WangHua Yu
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Nov 3, 2009·Immunity·Natalia Martin-OrozcoChen Dong
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Jan-Eric TurnerUlf Panzer
Mar 26, 2010·Nature Reviews. Immunology·Weiping Zou, Nicholas P Restifo
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyung LeeSarkis K Mazmanian
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Aug 6, 1881·British Medical Journal·R Virchow
Dec 15, 2010·Cancer Research·Sophie ViaudLaurence Zitvogel
Dec 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias LochnerGérard Eberl

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Citations

Nov 28, 2020·Frontiers in Immunology·Arianna BreviMatteo Bellone
Apr 15, 2021·Seminars in Immunopathology·Jöran LückeSamuel Huber
Apr 24, 2021·Frontiers in Cell and Developmental Biology·Qi LouMeng Zhao
Jul 15, 2021·Animal Nutrition·Jie PengYanhua Huang
Aug 20, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel B Horton, Anthony T Reder

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