Microbleeds may expand acutely after traumatic brain injury

Neuroscience Letters
Arnold TothAttila Schwarcz

Abstract

Susceptibility weighted imaging (SWI) is a very sensitive tool for the detection of microbleeds in traumatic brain injury (TBI). The number and extent of such traumatic microbleeds (TMBs) have been shown to correlate with the severity of the injury and the clinical outcome. However, the acute dynamics of TMBs have not been revealed so far. Since TBI is known to constitute dynamic pathological processes, we hypothesized that TMBs are not constant in their appearance, but may progress acutely after injury. We present here five closed moderate/severe (Glasgow coma scale≤13) TBI patients who underwent SWI very early (average=23.4 h), and once again a week (average=185.8 h) after the injury. The TMBs were mapped at both time points by a conventional radiological approach and their numbers and volumes were measured with manual tracing tools by two observers. TMB counts and extents were compared between time points. TMBs were detected in four patients, three of them displaying an apparent TMB change. In these patients, TMB confluence and apparent growth were detected in the corpus callosum, coronal radiation or subcortical white matter, while unchanged TMBs were also present. These changes caused a decrease in the TMB count associated...Continue Reading

References

Dec 1, 1995·Computer Methods and Programs in Biomedicine·F SchoonjansF H Comhaire
Aug 21, 2001·European Radiology·P M ParizelA M De Schepper
Sep 27, 2003·Epilepsia·John Bruns, W Allen Hauser
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Sep 6, 2005·Pediatric Neurology·Talin BabikianStephen Ashwal
Dec 20, 2005·Acta neurochirurgica·A Büki, J T Povlishock
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Robert A KnightDonald M Seyfried
Jan 24, 2009·Lancet Neurology·Steven M GreenbergUNKNOWN Microbleed Study Group
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsMonique M B Breteler
Apr 20, 2011·Journal of Neurotrauma·Miriam H BeauchampVicki Anderson
Oct 12, 2011·Current Opinion in Neurology·David J Sharp, Timothy E Ham
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Jun 27, 2012·Brain Injury : [BI]·Bram H J GeurtsPieter E Vos
Aug 31, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Kent Gøran MoenAnne Vik
Sep 6, 2012·Stroke; a Journal of Cerebral Circulation·Wenhong LiuUNKNOWN CASISP Study Group
Oct 16, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Miriam H BeauchampVicki Anderson
Jan 12, 2013·AJNR. American Journal of Neuroradiology·M B HulkowerM L Lipton
Aug 8, 2013·Stroke; a Journal of Cerebral Circulation·Ah-Ling ChengEric E Smith
Aug 22, 2013·Current Opinion in Anaesthesiology·Eva-Verena Schaible, Serge C Thal
Jan 28, 2014·The Behavioral and Brain Sciences·Ryan Ogilvie, Peter Carruthers
Sep 11, 2014·Neural Regeneration Research·Jun LiuYongquan Tian
Jul 15, 2015·JAMA Neurology·Nicholas M GreggWilliam E Klunk

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Citations

Mar 21, 2018·Radiology·Sven HallerFrederik Barkhof
Jul 20, 2018·Brain Injury : [BI]·Fabrício Stewan FeltrinClaudia C Leite
Sep 9, 2018·Current Medical Research and Opinion·Thomas J Humphries, Prasad Mathew
Feb 10, 2019·Journal of Neurosurgery. Pediatrics·Peter A FerrazzanoMichael J Bell
Oct 8, 2019·Journal of Neurotrauma·Sara H AndreasenHartwig R Siebner
Jul 28, 2016·Journal of Neuroscience Research·Shenandoah RobinsonLauren L Jantzie
Oct 15, 2019·Brain : a Journal of Neurology·Allison D GriffinLawrence L Latour
Jan 22, 2019·Journal of Alzheimer's Disease : JAD·Donna J CrossDavid G Cook
May 8, 2021·Journal of Neurosurgery·Mónica Patricia Herrera-MartinezMohammed Al-Dhahir

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