Microbubbles and ultrasound: from diagnosis to therapy

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
P A DijkmansO Kamp

Abstract

The development of ultrasound contrast agents, containing encapsulated microbubbles, has increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently used to enhance left ventricular opacification, increase Doppler signal intensity, and in myocardial perfusion imaging. Diagnostic imaging with contrast agents is performed with low acoustic pressure using non-linear reflection of ultrasound waves by microbubbles. Ultrasound causes bubble destruction, which lowers the threshold for cavitation, resulting in microstreaming and increased permeability of cell membranes. Interestingly, this mechanism can be used for delivery of drugs or genes into tissue. Microbubbles have been shown to be capable of carrying drugs and genes, and destruction of the bubbles will result in local release of their contents. Recent studies demonstrated the potential of microbubbles and ultrasound in thrombolysis. In this article, we will review the recent advances of microbubbles as a vehicle for delivery of drugs and genes, and discuss possible therapeutic applications in thrombolysis.

Citations

Jan 10, 2009·European Biophysics Journal : EBJ·U FarookM J Edirisinghe
Jan 1, 2013·Translational Stroke Research·Thilo HölscherArne Voie
Aug 11, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Cherry C Chen, Mark A Borden
Jul 8, 2009·Cardiovascular Research·Susan T Laing, David D McPherson
Sep 13, 2012·Investigative Ophthalmology & Visual Science·Walid F AbdallahMark S Humayun
Feb 6, 2013·Theranostics·Steven P WrennPeter A Lewin
Jun 13, 2014·Journal of Therapeutic Ultrasound·Marjan NabiliVesna Zderic
Dec 17, 2009·The Journal of the Acoustical Society of America·Juan TuThomas J Matula
May 27, 2009·Medical & Biological Engineering & Computing·Nico de JongMichel Versluis
Sep 6, 2014·The Journal of the Acoustical Society of America·Miguel A ParralesTyrone M Porter
Jun 30, 2006·IEEE Transactions on Nanobioscience·Neelesh R SomanSamuel A Wickline
Feb 14, 2008·IEEE Transactions on Bio-medical Engineering·Zachary G ForbesGary Friedman
Mar 13, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Truong An TranAyache Bouakaz
Mar 26, 2015·Future Oncology·Ahmed El Kaffas, Gregory J Czarnota
Aug 16, 2016·European Heart Journal Cardiovascular Imaging·Olivier VillemainEmmanuel Messas
Oct 6, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Juan DuEmad S Ebbini
Dec 22, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Claudio BaracchiniEnzo Ballotta
Jun 28, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Milija D MijajlovicNadezda Covickovic-Sternic
Nov 30, 2016·Biochemical and Biophysical Research Communications·Patrick RweiHao-Li Liu
Apr 26, 2016·Ultrasonics·Evan RonanRaffi Karshafian
Jan 24, 2015·Journal of Biotechnology·Mohan C M ArachchigeOleg A Andreev
May 21, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Rui André ProvidênciaAntónio Manuel Leitao-Marques
Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yiyao LiuMichihiro Nakamura
Oct 13, 2006·Medical Engineering & Physics·U FarookN Saffari
May 12, 2009·Ultrasound in Medicine & Biology·Dmitry GrishenkovGaio Paradossi
Aug 9, 2015·Foot & Ankle Specialist·Andrew R Hsu, George B Holmes
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Ghaleb A HusseiniAna M Martins

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.