PMID: 15248571Jul 14, 2004Paper

Microcalcification detection using cone-beam CT mammography with a flat-panel imager

Physics in Medicine and Biology
Xing GongStephen J Glick

Abstract

The purpose of this study was to investigate microcalcification detectability using CT mammography with a flat-panel imager. To achieve this, a computer simulation was developed to model an amorphous-silicon, CsI based flat-panel imager system using a linear cascaded model. The breast was modelled as a hemi-ellipsoid shape with composition of 50% adipose and 50% glandular tissue. Microcalcifications were modelled as small spheres having a composition of calcium carbonate. The results show that with a mean glandular dose equivalent to that typically used in two-view screening mammography, CT mammography with a flat-panel detector is capable of providing images where most microcalcifications are detectable. A receiver operating characteristic (ROC) study was conducted by five physicist observers viewing simulated CT mammography reconstructions. The results suggest that the microcalcification with its diameter equal to or greater than 0.175 mm can be detected with an average area under the ROC curve (AUC) greater than 0.95 using 0.1 or 0.2 mm pixelized detectors. The results also indicate that the optimal pixel size of the detector is around 0.2 mm for microcalcification detection, based on the trade-off between detectability of m...Continue Reading

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Citations

Oct 21, 2006·Journal of Mammary Gland Biology and Neoplasia·John M BooneThomas R Nelson
May 18, 2007·Annual Review of Biomedical Engineering·Stephen J Glick
Mar 3, 2011·Medical Physics·Michaela WeigelWilli A Kalender
Jun 22, 2006·Future Oncology·John M Boone, Karen K Lindfors
Jul 5, 2012·Medical Physics·Martin HupferWilli A Kalender
Apr 6, 2013·Medical Physics·J Michael O'ConnorStephen J Glick
Feb 7, 2007·Medical Physics·Alexander L C KwanShih-Ying Huang
Dec 17, 2008·Medical Physics·Andrew Karellas, Srinivasan Vedantham
Oct 9, 2009·Medical Physics·Lingyun ChenChris C Shaw
Apr 22, 2009·Medical Physics·Reema Bhagtani, Taly Gilat Schmidt
Nov 4, 2005·Medical Physics·Alexander L C KwanNikula Shah
Jan 10, 2013·Medical Physics·Srinivasan VedanthamAndrew Karellas
Oct 6, 2014·Medical Physics·Adrian A SanchezXiaochuan Pan
Mar 17, 2010·European Journal of Radiology·Ali HassanHatem Alkadhi
Nov 3, 2010·IEEE Transactions on Medical Imaging·Mini DasStephen J Glick
Jul 2, 2015·Medical Physics·Antonio SarnoPaolo Russo
Apr 7, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Jan D KuttigWilli A Kalender
Dec 28, 2010·International Journal of Cardiology·Ibrahim AboshadyGregory W Gladish
Oct 31, 2015·International Journal of Computer Assisted Radiology and Surgery·Xiaolei QuChris C Shaw
Mar 18, 2017·Medical Physics·Andrew M HernandezJohn M Boone
Apr 21, 2011·Molecular Imaging·Kazumasa InoueJohn V Frangioni
Nov 21, 2013·Physics in Medicine and Biology·Travis JohnsonSabee Molloi
Apr 19, 2011·Acta Radiologica·Hubert GuflerFolker Ernst Franke
Dec 5, 2020·Physics in Medicine and Biology·Peymon Ghazi

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