PMID: 9440867Jan 24, 1998Paper

Microcarrier enhanced survival of human and rat fetal ventral mesencephalon cells implanted in the rat striatum

Cell Transplantation
S SaportaP R Sanberg

Abstract

The transplantation of tissue containing dopamine-producing cells into the mammalian central nervous system is an emerging treatment for Parkinson's disease, despite relatively poor survival of implanted tissue. Recent evidence has suggested that Cytodex microcarriers enhance the survival of dopaminergic rat chromaffin cells transplanted into the rat striatum in the absence of immunosuppression. The current study was undertaken to evaluate the survival of rat and human fetal ventral mesencephalic neurons (VM) implanted alone or after attachment to microcarriers in the striatum of rats without immunosuppression. Rat fetal VM neurons demonstrated enhanced survival in the rat striatum when transplanted on microcarriers, compared to their transplantation alone during the 3-mo period examined in the present study. Transplants of human fetal VM neurons on microcarriers also survived remarkably well in the rat striatum without systemic immunosuppression. In contrast, human fetal VM cells transplanted alone into the rat striatum did not survive without systemic immunosuppression. There was no evidence of TH fiber sprouting in the vicinity of any transplant site. These data indicated that Cytodex microcarriers provide enhanced survival ...Continue Reading

Citations

Jun 17, 2014·International Journal of Molecular Sciences·Francisca S Y WongAmy C Y Lo
Jul 5, 2005·Expert Opinion on Investigational Drugs·J H Dinsmore
Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Natividad P Stover, Ray L Watts
Nov 17, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·N J TawilT Mustoe
Nov 19, 2010·Tissue Engineering. Part B, Reviews·Yella MartinJustin R Sharpe

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