Microcarriers for Upscaling Cultured Meat Production

Frontiers in Nutrition
Vincent BodiouMark J Post

Abstract

Due to the considerable environmental impact and the controversial animal welfare associated with industrial meat production, combined with the ever-increasing global population and demand for meat products, sustainable production alternatives are indispensable. In 2013, the world's first laboratory grown hamburger made from cultured muscle cells was developed. However, coming at a price of $300.000, and being produced manually, substantial effort is still required to reach sustainable large-scale production. One of the main challenges is scalability. Microcarriers (MCs), offering a large surface/volume ratio, are the most promising candidates for upscaling muscle cell culture. However, although many MCs have been developed for cell lines and stem cells typically used in the medical field, none have been specifically developed for muscle stem cells and meat production. This paper aims to discuss the MCs' design criteria for skeletal muscle cell proliferation and subsequently for meat production based on three scenarios: (1) MCs are serving only as a temporary substrate for cell attachment and proliferation and therefore they need to be separated from the cells at some stage of the bioprocess, (2) MCs serve as a temporary substr...Continue Reading

References

Nov 1, 1977·Biotechnology and Bioengineering·R E SpierK Bolt
Jan 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M V DodsonB D Mathison
Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
Jul 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H H Vandenburgh, P Karlisch
Apr 1, 1971·Journal of Cellular Physiology·L Weiss, R Zeigel
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·M StokerV Waxman
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·I Giaever, C R Keese
Jan 26, 1996·The Journal of Biological Chemistry·F EchtermeyerK von der Mark
Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Oct 8, 1999·Emerging Infectious Diseases·P S MeadR V Tauxe
Nov 30, 2000·Medical & Biological Engineering & Computing·C E TorganW E Kraus
Nov 27, 2001·Science·E CukiermanK M Yamada
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Amy M CollinsworthGeorge A Truskey
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Courtney A PowellHerman H Vandenburgh
Jan 31, 2003·The Journal of Biological Chemistry·Joshua R Sanes
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
Feb 18, 2004·Biomaterials·Galen B SchneiderJohn Keller
Mar 2, 2005·Tissue Engineering·Cameron J WilsonMark J Pearcy
Jun 14, 2005·Biomaterials·Thomas FreierMolly S Shoichet
Jul 7, 2005·Tissue Engineering·P D EdelmanJ G Matheny
Dec 31, 2005·EXS·David I Pattison, Michael J Davies
Aug 3, 2006·Journal of Biomedical Materials Research. Part a·Akon HiguchiShizue Hayashi Natori
Feb 3, 2007·Biotechnology Progress·Simone FrauenschuhJochen Ringe
Apr 12, 2007·Experimental Cell Research·Hideaki FujitaMakoto Kanzaki
May 1, 2007·Biomaterials·Li-Chong Xu, Christopher A Siedlecki
Dec 29, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masayasu MieEiry Kobatake
Mar 20, 2008·Journal of the Royal Society, Interface·Monika RumplerPeter Fratzl
May 1, 1983·Biotechnology and Bioengineering·J VaraniJ A Wass
Sep 6, 2008·Journal of Biotechnology·Blaine Wesley PhillipsJeremy Micah Crook
Mar 17, 2009·Tissue Engineering. Part C, Methods·Masahiro Kino-OkaMasahito Taya

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Citations

Aug 4, 2020·Journal of Animal Science·Cameron FaustmanSteven A Zinn
Jun 23, 2020·Biotechnology and Bioengineering·Mariana P HangaIvan Wall
Sep 29, 2020·Frontiers in Psychology·Sghaier ChrikiJean-François Hocquette
Dec 1, 2020·Frontiers in Nutrition·Caroline Faria BellaniChe J Connon
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Kwang-Hwan ChoiChang-Kyu Lee
Jan 21, 2021·Acta Biomaterialia·Shengyong Ng, Motoichi Kurisawa
Mar 27, 2021·Annual Review of Food Science and Technology·Regine EiblDieter Eibl
May 21, 2021·Veterinary Research·Frederic DessaugeKarl Rouger
May 22, 2021·Food Science of Animal Resources·Tae Kyung HongSung Gu Han
Jun 22, 2021·Critical Reviews in Biotechnology·Jasmine Si Han SeahDeepak Choudhury
Jul 3, 2021·Foods·Balamuralikrishnan BalasubramanianSungkwon Park
Jul 25, 2021·International Journal of Molecular Sciences·Jacob ReissMasatoshi Suzuki
Aug 28, 2021·Journal of Animal Science and Technology·Pavan KumarAwis Qurni Sazili
Oct 12, 2021·Comprehensive Reviews in Food Science and Food Safety·Kimberly J OngJo Anne Shatkin

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