Microchimerism in alopecia areata

International Journal of Dermatology
Erdinç TerziŞenay Görücü Yilmaz

Abstract

Autoimmunity is the main etiopathogenetic factor in alopecia areata. Microchimerism is the existence of allogeneic DNA in a living creature. There are variable studies investigating the role of microchimerism on the etiopathogenesis of autoimmune diseases. To our knowledge, no report has investigated the relationship between microchimerism and alopecia areata. We aimed to investigate the possible role of microchimerism on alopecia areata. We analyzed SRY gene levels as indicators of fetal microchimerism in our patient group. The patients were 29 women with alopecia areata, over 18 years old, who had visited our clinic between 2010 and 2013. Patients were divided into two groups; group 1 consisted of 14 patients having a son and group 2, 15 patients either nulliparous or having a daughter. Seventeen of 29 patients (58.6%) and four of 103 controls (3.9%) showed presence of an SRY gene. The difference between the patient and control groups was statistically significant (P < 0.001). As a result of our study, microchimerism may be associated with the etiopathogenesis of alopecia areata. However, we think there is a need for a larger series of studies to support this hypothesis.

References

Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
Sep 18, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Rubbia-BrandtA Hadengue
Feb 26, 2000·Immunology Today·S AractingiE D Carosella
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N C LambertJ L Nelson
Sep 13, 2002·European Journal of Internal Medicine·S Régnier, S Aractingi
Nov 16, 2004·Biochemical and Biophysical Research Communications·Yu WangMasatsugu Hori
Sep 6, 2005·Arthritis and Rheumatism·Anne M StevensJ Lee Nelson
Jun 23, 2007·Annals of the Rheumatic Diseases·Idske C L Kremer HovingaIngeborg M Bajema
Aug 27, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Michele LeducKiarash Khosrotehrani
Jul 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·P I KurtulusM E Erdal
Nov 20, 2012·Dermatologic Clinics·Abdullah Alkhalifah
Apr 17, 2013·Immunogenetics·Yuko HaidaAkira Oka
Jun 26, 2013·European Journal of Dermatology : EJD·Cerrene N Giordano, Animesh A Sinha
Oct 24, 2013·Clinical & Developmental Immunology·Taisuke Ito
Jan 1, 2014·International Journal of Dermatology·Ruken AlpMehmet E Erdal

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Citations

Aug 16, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·W Niepiekło-MiniewskaP Kuśnierczyk

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