Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Current Opinion in Neurobiology
Jan-Marino RamirezNathan A Baertsch

Abstract

Rhythmicity is critical for the generation of rhythmic behaviors and higher brain functions. This review discusses common mechanisms of rhythm generation, including the role of synaptic inhibition and excitation, with a focus on the mammalian respiratory network. This network generates three phases of breathing and is highly integrated with brain regions associated with numerous non-ventilatory behaviors. We hypothesize that during evolution multiple rhythmogenic microcircuits were recruited to accommodate the generation of each breathing phase. While these microcircuits relied primarily on excitatory mechanisms, synaptic inhibition became increasingly important to coordinate the different microcircuits and to integrate breathing into a rich behavioral repertoire that links breathing to sensory processing, arousal, and emotions as well as learning and memory.

References

Apr 27, 2018·PLoS Computational Biology·Jessica AusbornIlya A Rybak
May 2, 2018·Annual Review of Neuroscience·Jan-Marino Ramirez, Nathan A Baertsch
Aug 16, 2018·Physiology·Jan-Marino Ramirez, Nathan A Baertsch
Jun 14, 2018·Journal of Neurophysiology·Muriel Thoby-Brisson
Aug 19, 2017·Scientific Reports·John A HayesChristopher A Del Negro
Feb 28, 2018·Nature Communications·Nathan A BaertschJan Marino Ramirez
Mar 29, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nathan A BaertschJan-Marino Ramirez
Jun 16, 2017·Journal of Neurophysiology·Kameron Decker HarrisEric Shea-Brown
Nov 30, 2019·Chaos·Rosangela Follmann, Epaminondas Rosa
Mar 17, 2017·F1000Research·Tatiana M Anderson, Jan-Marino Ramirez

Related Concepts

Biological Neural Networks
Vigilance, Cortical
Periodicity
Neurons
Arousal
Brain Function
Metabolic Inhibition
Inhibition of Synaptic Transmission
Rhythmic Process (Biological)
Sensory Process

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