PMID: 11320035Apr 26, 2001Paper

Microcirculation patterns other than loops and networks in choroidal and ciliary body melanomas

Ophthalmology
R FolbergA J Maniotis

Abstract

To provide ophthalmologists and pathologists with expanded criteria for separating patients at high risk of metastatic melanoma from those at low risk on the basis of microcirculation patterns in choroidal and ciliary body melanomas. Tissue culture studies and observational case series. The pattern-forming ability of four uveal melanoma cell lines of varying degrees of aggressive behavior was studied in vitro. Histologic sections of 234 eyes removed for choroidal or ciliary body melanoma were studied for the presence of microcirculation patterns. The study was divided into two phases: the study of histologic sections of eyes removed for choroidal and ciliary body melanomas and observations on the in vitro behavior of cultured melanoma cells of varying degrees of invasive behavior. The presence or absence of each of nine microcirculation patterns was recorded from tissue sections, and interrelationships between different patterns were explored statistically. In vitro reconstitution of patterns and a study of the interrelationships of patterns in histologic sections was carried out. In the in vitro studies, uveal melanoma cell lines of varying degrees of aggressive potential were cultured to observe the development of architectur...Continue Reading

References

May 1, 1992·Survey of Ophthalmology·D M AlbertJ K Willson
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Nov 1, 1996·Survey of Ophthalmology·C M Mooy, P T De Jong
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Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis

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Citations

Jun 14, 2005·Acta Ophthalmologica Scandinavica·R ForteG De Rosa
Oct 1, 2006·Expert Review of Ophthalmology·D Jackson ColemanSuzanne Daly
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Robert Folberg, Andrew J Maniotis
Apr 28, 2017·Journal of Computer Assisted Tomography·Wenbo WeiMichael V Knopp

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