PMID: 7526117Jan 1, 1994Paper

Microcirculation research, angiogenesis, and microsurgery

Microsurgery
J M FrankJ H Barker

Abstract

Angiogenesis, the formation of new blood vessels, is essential to a variety of normal and pathologic processes such as wound healing and tumor growth. In microsurgery the development of new vessels between the transferred tissue and the recipient bed is critical to the final outcome of the reconstruction. Several experimental models have been previously developed to study angiogenesis and the effect that new substances have on regulating this process, but they lack the ability to make quantitative measurements. Therefore, we have developed an animal model using the homozygous (hr/hr) hairless mouse ear; by using intravital microscopy and computer-assisted analysis, angiogenesis can be quantitatively measured. Using this model we showed that basic fibroblast growth factor and transforming growth factor beta significantly increased total vessel length by 32% and 63%, respectively, during 20 days following subcutaneous injection. In this paper the importance of angiogenesis research to reconstructive microsurgery is presented and discussed.

References

Oct 1, 1978·British Journal of Plastic Surgery·M J BlackL A Sharzer
Oct 1, 1977·Nature·P J PolveriniE R Unanue
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·I BondárK Messmer
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·I IshiwataH Ishikawa
Sep 15, 1987·Biochemical and Biophysical Research Communications·A HayekA Baird
Oct 22, 1987·Nature·J Folkman, M Klagsbrun
Jun 1, 1989·Plastic and Reconstructive Surgery·J H BarkerK Messmer
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Feb 1, 1974·Journal of the National Cancer Institute·M A GimbroneJ Folkman
Dec 11, 1980·Nature·J Folkman, C Haudenschild
Jan 1, 1980·Scandinavian Journal of Plastic and Reconstructive Surgery·T Albrektsson
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·B EndrichK Messmer
Aug 1, 1980·Plastic and Reconstructive Surgery·J V BoykinR N Pittman
Jan 1, 1993·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M KamlerK Messmer

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Citations

Nov 6, 2012·The Journal of Surgical Research·Anna L SanderHeike Jakob
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anna L SanderJohannes M Frank
Aug 24, 2001·Developmental Biology·S Zhao, P A Overbeek
Apr 25, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus M ZimmerHans Becker
Apr 5, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Katharina SommerAnna L Sander
Jun 29, 2001·British Journal of Plastic Surgery·O AhmedN B Hart

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