Microcirculatory changes and skeletal muscle oxygenation measured at rest by non-infrared spectroscopy in patients with and without diabetes undergoing haemodialysis

Critical Care : the Official Journal of the Critical Care Forum
R A De BlasiPaolo Menè

Abstract

Haemodialysis has direct and indirect effects on skin and muscle microcirculatory regulation that are severe enough to worsen tolerance to physical exercise and muscle asthenia in patients undergoing dialysis, thus compromising patients' quality of life and increasing the risk of mortality. In diabetes these circumstances are further complicated, leading to an approximately sixfold increase in the incidence of critical limb ischaemia and amputation. Our aim in this study was to investigate in vivo whether haemodialysis induces major changes in skeletal muscle oxygenation and blood flow, microvascular compliance and tissue metabolic rate in patients with and without diabetes. The study included 20 consecutive patients with and without diabetes undergoing haemodialysis at Sant Andrea University Hospital, Rome from March to April 2007. Near-infrared spectroscopy (NIRS) quantitative measurements of tissue haemoglobin concentrations in oxygenated [HbO2] and deoxygenated forms [HHb] were obtained in the calf once hourly for 4 hours during dialysis. Consecutive venous occlusions allowed one to obtain muscular blood flow (mBF), microvascular compliance and muscle oxygen consumption (mVO2). The tissue oxygen saturation (StO2) and conten...Continue Reading

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Citations

Dec 20, 2015·Microvascular Research·William H NugentAleksander S Golub
Aug 10, 2010·Journal of Renal Care·Maria KastrouniPolichronis Alivanis
Nov 23, 2016·World Journal of Nephrology·Haruhisa MiyazawaYoshiyuki Morishita
Dec 6, 2018·Seminars in Dialysis·Clare MacEwenChristopher Pugh
May 4, 2018·BioMed Research International·Kinga Węgrzynowska-TeodorczykMarek Woźniewski
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis

Methods Mentioned

BETA
amputation

Related Concepts

Diabetes Mellitus
Hemodialysis
Microcirculation
Oxygen Consumption
Rest
Soleus Muscle Structure
Spectroscopy, Near-Infrared
Amputation
Blood
Diabetes

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