Microcirculatory Improvement Induced by Laparoscopic Sleeve Gastrectomy Is Related to Insulin Sensitivity Retrieval

Obesity Surgery
Stefano MinistriniLeonella Pasqualini

Abstract

Microvascular dysfunction is a potential factor explaining the association of obesity, insulin resistance, and vascular damage in morbidly obese subjects. The purpose of the study was to evaluate possible determinants of microcirculatory improvement 1 year after laparoscopic sleeve gastrectomy (LSG) intervention. Thirty-seven morbidly obese subjects eligible for bariatric surgery were included in the study. Post-occlusive reactive hyperemia (PORH) of the forearm skin was measured as area of hyperemia (AH) by laser-Doppler flowmetry before LSG and after a 1-year follow-up. After intervention, we observed a significant reduction in BMI, HOMA index, HbA1c, and a significant increase of AH in all patients after surgery; this variation was significant only in those patients having insulin resistance or prediabetes/diabetes. Although significant correlation between the increase of AH and the reduction of both BMI, HOMA index, and HbA1c was observed, BMI was the only independent predictor of AH variation after LSG at the linear regression analysis. Our study shows that LSG intervention is correlated with a significant improvement in the microvascular function of morbidly obese subjects; this improvement seems to be related to the base...Continue Reading

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Citations

Dec 7, 2018·Journal of Occupational and Environmental Medicine·Kristine KrajnakKhachatur Sarkisian
Nov 30, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Barbara GryglewskaTomasz Grodzicki
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Aug 28, 2019·Neurobiology of Disease·Joy Jones BuieCatrina Sims-Robinson
Jul 13, 2021·JAMA Network Open·Noyan GokceMelissa G Farb

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