Microcrack accumulation at different intervals during fatigue testing of compact bone

Journal of Biomechanics
Fergal J O'BrienT Clive Lee

Abstract

Fatigue damage in bone occurs in the form of microcracks. This microdamage contributes to the formation of stress fractures and acts as a stimulus for bone remodelling. A technique has been developed, which allows microcrack growth to be monitored during the course of a fatigue test by the application of a series of fluorescent chelating agents. Specimens were taken from bovine tibiae and fatigue tested in cyclic compression at a stress range of 80MPa. The specimens were stained before testing with alizarin and up to three other chelating agents were applied during testing to label microcracks formed at different times. Microcracks initiated in interstitial bone in the early part of a specimen's life. Further accumulation of microcracks is then suppressed until the period late in the specimen's life. Microcracks were found to be longer in the longitudinal than in the transverse direction. Only a small proportion of cracks are actively propagating; these are longer than non-propagating cracks. These results support the concept of a microstructural barrier effect existing in bone, whereby cracks initiate easily but slow down or stop at barriers such as cement lines.

References

Jul 1, 1989·Calcified Tissue International·M R Forwood, A W Parker
Jan 1, 1985·Journal of Biomechanics·D B BurrE L Radin
Jan 1, 1982·Journal of Biomechanics·R B Martin, D B Burr
Aug 1, 1994·Journal of Biomechanics·P J Prendergast, D Taylor
Apr 1, 1993·Journal of Biomechanics·D B Burr, R B Martin
Jul 22, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T M BoyceM B Schaffler
Jul 22, 1998·Journal of Biomechanics·D B BurrR Pidaparti
Nov 25, 1998·Journal of Anatomy·T C LeeW C Hayes
Jan 9, 1999·Journal of Biomechanics·D Taylor, T C Lee
Mar 27, 1999·Journal of Biomechanics·K J JepsenD J Krzypow
Jul 28, 1999·Irish Journal of Medical Science·T C Lee, D Taylor
Jan 5, 2000·Bone·R B Martin
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T C LeeW C Hayes
Dec 16, 2000·Journal of Anatomy·F J O'BrienT C Lee
Apr 6, 2002·Journal of Biomechanics·Fergal J O'BrienT Clive Lee

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Citations

Sep 15, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jan G HazenbergT Clive Lee
May 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T L WillettM D Grynpas
May 28, 2010·Biomechanics and Modeling in Mechanobiology·Ridha HambliClaude-Laurent Benhamou
Dec 16, 2006·Annals of Biomedical Engineering·P McDonnellD O'Mahoney
Sep 19, 2009·Annals of Biomedical Engineering·L P MullinsM S Bruzzi
Jul 23, 2005·Current Osteoporosis Reports·Fergal J O'BrienT Clive Lee
Jul 28, 2004·Journal of Biomechanics·O S SobelmanR B Martin
May 24, 2005·Journal of Biomechanics·J J KruzicR O Ritchie
Dec 14, 2007·Journal of Biomechanics·Victor KosmopoulosTony S Keller
Oct 11, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Lei WangShijing Qiu
Oct 6, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Susan Mischinski, Ani Ural
Jan 20, 2006·The Journal of the Acoustical Society of America·Marie MullerPaul A Johnson
Sep 7, 2012·PloS One·Max LangerFrançoise Peyrin
Aug 21, 2013·Biomechanics and Modeling in Mechanobiology·Anjali SinghalDavid C Dunand
Mar 14, 2014·Biomechanics and Modeling in Mechanobiology·Finn DonaldsonRalph Müller
Oct 5, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Yutian ShuLaura R McCabe
Sep 16, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Langer, F Peyrin
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zilan X LinXiaodong Li
Dec 24, 2011·Medical Engineering & Physics·Nicholas A RussellWilliam R Walsh
Mar 10, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Vincent MathieuGuillaume Haiat
Sep 2, 2011·Journal of Biomechanics·Jessica O GreenRobert E Guldberg
Oct 5, 2010·Acta Biomaterialia·Robb M KulinKenneth S Vecchio
Nov 26, 2010·Journal of the Mechanical Behavior of Biomedical Materials·Robb M KulinKenneth S Vecchio
Apr 28, 2009·Journal of Biomechanics·Matthew D Landrigan, Ryan K Roeder
Jan 1, 2008·Journal of the Mechanical Behavior of Biomedical Materials·J J Kruzic, R O Ritchie
Oct 24, 2006·Journal of Biomechanics·Ani Ural, Deepak Vashishth
Jan 20, 2006·Journal of Anatomy·S MohsinT C Lee
Oct 5, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Orlaith BrennanFergal J O'Brien
Jan 15, 2010·Clinical Oral Implants Research·Abdulhadi WarrethNoel Claffey
Jul 28, 2011·Journal of Biomedical Materials Research. Part a·Ryan D Ross, Ryan K Roeder
Nov 17, 2007·Journal of Biomechanics·S DendorferJ Hammer
Feb 17, 2005·Journal of Biomechanics·Srinidhi NagarajaRobert E Guldberg

❮ Previous
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