Microcystin - LR exposure causes cardiorespiratory impairments and tissue oxidative damage in trahira, Hoplias malabaricus

Ecotoxicology and Environmental Safety
Nathan Dias MartinsDiana Amaral Monteiro

Abstract

This study investigated the effect of microcystin-LR (MC-LR) on in vivo cardiorespiratory function and on tissue biomarkers of oxidative stress in gills and liver of the trahira, a neotropical freshwater fish. Trahira were treated with an intraperitoneal injection of 100 µg MC-LR.kg-1 body mass or a saline, with the toxic effects of MC-LR then evaluated after 48 h. Rates of oxygen uptake (V̇O2) did not differ significantly between Control and the exposed group (Mcys), but exposure to MC-LR significantly reduced O2 extraction in the Mcys group at all O2 tensions. This was associated with higher gill ventilation volume (V̇G) in the Mcys group at all O2 tensions except 140 and 120 mmHg, and a higher tidal volume (VT) of the Mcys group at all tensions except 140 mmHg. Heart rate was also higher in the Mcys group, significantly so at an O2 tension of 40 mmHg. In the liver of trahira, exposure to MC-LR has significant effects on antioxidant defense systems, inducing a significant increase in the activity of the (GPx) glutathione peroxidase enzyme (100%) and in the reduced glutathione (GSH) content (70%) compared to the control group, but no effects on superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) enzy...Continue Reading

Citations

Feb 27, 2020·Environmental Toxicology and Chemistry·Marcelo Gustavo PaulinoMarisa Narciso Fernandes
Sep 5, 2019·Toxins·Linghui CaoFei Yang
Jul 17, 2020·The Science of the Total Environment·Xinghou HePing Ding
Sep 17, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Diana A MonteiroDavid J McKenzie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.