Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro

Toxicology Letters
Yu ChenChao Liu

Abstract

This study aimed to investigate the toxic effects of microcystin-LR (MC-LR), which is released from several bloom-forming cyanobacteria, on the glucose metabolism of pancreatic β cells in vivo and in vitro. Male mice and the pancreatic MIN6 cells were respectively treated with varying concentrations of MC-LR. After 3- or 6- months of MC-LR exposure, increase in the body weight of mice was found to be inhibited, and the structure of their pancreatic tissues was damaged with impaired glucose tolerance and impaired insulin secretion. Further, these toxic effects became more pronounced with time and with increased dosages. Direct cytotoxic effects of MC-LR were observed in the MIN6 pancreatic β-cells possibly due to their expression of the MC-LR specific transporter. MC-LR entered the MIN6 cells that significantly reduced the cell viability. Both in vivo and in vitro experiments demonstrated that MC-LR was able to induce apoptosis, possibly associated with mitochondrial damage. Above all, these findings implied that MC-LR may be transported into the pancreatic β cells and cause subsequent cytotoxicity.

Citations

Feb 2, 2021·Ecotoxicology and Environmental Safety·Hehua LeiLimin Zhang
Aug 28, 2021·Toxicon : Official Journal of the International Society on Toxinology·Yu ChenZhaoyao Chen

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