PMID: 16515466Mar 7, 2006Paper

Microcystin produces disparate effects on liver cells in a dose dependent manner

Mini Reviews in Medicinal Chemistry
Lars Herfindal, Frode Selheim

Abstract

In this review we present recent studies on the effects of the protein phosphatase inhibitor microcystin on mammalian cells. Whereas high concentrations of microcystin promote liver cell death induced by ROS signalling without the involvement of typical apoptotic proteins, intermediate doses activate classic apoptotic pathways. Low concentrations however, increase liver cell survival and proliferation, and can cause primary liver cancer.

Citations

May 11, 2013·Chemosphere·Xianing HuangKangding Gu
Feb 18, 2010·International Journal of Molecular Sciences·Alexandre Campos, Vitor Vasconcelos
Jun 17, 2014·Toxicon : Official Journal of the International Society on Toxinology·Liang ChenPing Xie
May 2, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Małgorzata A BrodaBarbara Rzeszotarska
Jun 25, 2010·Chembiochem : a European Journal of Chemical Biology·Jouni JokelaKaarina Sivonen
Sep 27, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Carina MenezesPaulo Pereira
Jun 25, 2016·Environmental Science & Technology·Xinran ZhangErnest R Blatchley Iii
Nov 5, 2016·Toxicon : Official Journal of the International Society on Toxinology·Xueting WangXiaodong Han
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chao SongLing-Ling Wu
Mar 7, 2021·International Journal of Environmental Research and Public Health·Wenqing XiaoKangding Gu
Mar 3, 2010·Environmental Science & Technology·Grzegorz JasionekDimitri B Papkovsky

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