MicroDAIMON study: Microcirculatory DAIly MONitoring in critically ill patients: a prospective observational study

Annals of Intensive Care
Claudia ScorcellaAbele Donati

Abstract

Until now, the prognostic value of microcirculatory alterations in critically ill patients has been mainly evaluated in highly selected subgroups. Aim of this study is to monitor the microcirculation daily in mixed group of Intensive Care Unit (ICU)-patients and to establish the association between (the evolution of) microcirculatory alterations and outcome. This is a prospective longitudinal observational single-centre study in adult patients admitted to a 12-bed ICU in an Italian teaching hospital. Sublingual microcirculation was evaluated daily, from admission to discharge/death, using Sidestream Dark Field imaging. Videos were analysed offline to assess flow and density variables. Laboratory and clinical data were recorded simultaneously. A priori, a Microvascular Flow Index (MFI) < 2.6 was defined as abnormal. A binary logistic regression analysis was performed to evaluate the association between microcirculatory variables and outcomes; a Kaplan-Meier survival curve was built. Outcomes were ICU and 90-day mortality. A total of 97 patients were included. An abnormal MFI was present on day 1 in 20.6%, and in 55.7% of cases during ICU admission. Patients with a baseline MFI < 2.6 had higher ICU, in-hospital and 90-day mortali...Continue Reading

Associated Clinical Trials

References

Sep 17, 2003·Critical Care : the Official Journal of the Critical Care Forum·Ryon M BatemanChristopher G Ellis
Dec 24, 2003·American Heart Journal·Daniel De BackerJean-Louis Vincent
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Jul 3, 2008·Intensive Care Medicine·Stephen TrzeciakUNKNOWN Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators
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Feb 25, 2014·Critical Care Medicine·Guillaume TachonJacques Duranteau
Aug 16, 2014·Critical Care Medicine·Namkje A R VellingaUNKNOWN microSOAP Study Group
Apr 2, 2015·Current Opinion in Critical Care·Vanina S Kanoore EdulArnaldo Dubin
Feb 11, 2016·Critical Care : the Official Journal of the Critical Care Forum·Michael J Massey, Nathan I Shapiro
Aug 20, 2016·Journal of Clinical Monitoring and Computing·Elisa DamianiAbele Donati

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Citations

Apr 26, 2019·Current Opinion in Critical Care·Daniel De Backer
Dec 14, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Laura A MaitozaRichard W Pierce
Nov 20, 2019·Shock·Martine E BolGerry A F Nicolaes
Sep 15, 2020·Clinical Hemorheology and Microcirculation·Raphael Romano BrunoChristian Jung
Jun 23, 2020·Clinical Hemorheology and Microcirculation·Romeo Martini
May 7, 2020·Journal of Clinical Monitoring and Computing·Jonny CoppelEdward Gilbert-Kawai
May 15, 2020·Critical Care : the Official Journal of the Critical Care Forum·Matthijs M den OsNicole A M Dekker
May 22, 2020·Annals of Intensive Care·Elisa DamianiAbele Donati
Nov 10, 2020·Microvascular Research·Sheng JiangGuolong Cai
Feb 13, 2021·Current Opinion in Anaesthesiology·Daniel De BackerGustavo A Ospina-Tascón
Mar 21, 2021·Critical Care : the Official Journal of the Critical Care Forum·Alexandros RovasPhilipp Kümpers
Jul 10, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yu ZhangGuanhua Li

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Clinical Trials Mentioned

NCT02649088

Software Mentioned

Automated Vascular Analysis
SPSS
MicroDAIMON
AVA
GraphPad Prism

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