Microdeletions of the Y chromosome and intracytoplasmic sperm injection: from gene to clinic

Human Reproduction
J A KremerH M Merkus

Abstract

Intracytoplasmic sperm injection (ICSI) is a successful treatment option for severe male infertility, although the aetiology of the disorder remains unclear in most cases. Recently, microdeletions in the AZF region of the Y chromosome have been detected in men with azoospermia or severe oligozoospermia. In this study we investigated the prevalence of microdeletions in the AZF region of the Y chromosome in a population of men undergoing ICSI, and looked for clinical characteristics of men with and without this deletion. Blood was drawn from 164 men, who were on the waiting list for ICSI treatment: 19 were azoospermic, 111 oligozoospermic and 34 normozoospermic (after previous total fertilization failure). A total of 100 men with proven fertility served as a control. Microdeletions in the AZFc region were present in seven of the 111 oligozoospermic men (6.3%). Compared with oligozoospermic men without microdeletions, men with microdeletions had a lower concentration of follicle stimulating hormone (FSH), a lower number of motile spermatozoa and a lower frequency of abnormal findings at andrological history or examination. No microdeletions were found in the azoospermic, normozoospermic and control groups. In conclusion, microdele...Continue Reading

Citations

Apr 26, 2013·Journal of Assisted Reproduction and Genetics·Marwan AlhalabiAmmar Madania
Jun 27, 2002·Current Urology Reports·D M Nudell, P J Turek
Jun 13, 2003·Fertility and Sterility·Judith GianottenFulco van der Veen
Jun 13, 2003·Fertility and Sterility·Tanja KunejBorut Peterlin
Mar 29, 2000·Theriogenology·Y J MénézoJ L Pouly
Aug 26, 1998·Clinical Endocrinology·I Huhtaniemi, K Pettersson
Jun 15, 1999·International Journal of Andrology·I SeiferY J Bignon
Oct 6, 1999·International Journal of Andrology·M SimoniP H Vogt
Jun 13, 2000·International Journal of Andrology·S J Silber
Feb 13, 2001·International Journal of Andrology·A FrielM Glennon
Aug 5, 2003·Reproduction, Fertility, and Development·Kyung Ho LeeKunsoo Rhee
Dec 20, 2002·Genetic Testing·Patricia De C PieriCarlos A Moreira-Filho
Jun 17, 2008·Genetic Testing·Ciğdem CinarAhmet Ilter Güney
Oct 23, 2008·Human Reproduction·G H WoldringhE F P M Schoenmakers
Jul 25, 2000·Molecular Human Reproduction·C Le BourhisJ P Dadoune
Jun 10, 1998·Current Opinion in Obstetrics & Gynecology·G WrightS E Smith
Apr 9, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Regina BehulovaVanda Repiska
Nov 5, 1999·Human Reproduction·P L ChangS Brown
Nov 30, 2000·Journal of Endocrinological Investigation·S ParacchiniC Tyler-Smith
Mar 30, 2006·Reproductive Biomedicine Online·Hesham F KayedAshraf Abdrazik
Mar 3, 2004·Reproductive Biomedicine Online·Ragaa Mansour
Sep 13, 2005·BJU International·Gwendolyn H WoldringhEric J H Meuleman
Aug 16, 1997·Lancet·P A In't VeldR F Weber
Dec 1, 2000·Human Reproduction·J P SiffroiJ P Dadoune
Jul 17, 2007·American Journal of Medical Genetics. Part a·D StemkensJ C Giltay
Feb 9, 1999·Prenatal Diagnosis·E D KimD J Lamb
Apr 11, 2001·Endocrine Reviews·C ForestaA Ferlin
Nov 30, 2000·Journal of Endocrinological Investigation·B Maurer, M Simoni
Aug 5, 2004·Journal of Andrology·Ron J T van GoldeJan A M Kremer
Jan 9, 2003·The Urologic Clinics of North America·Peter J BurrowsLarry I Lipshultz
Jun 28, 2011·Fertility and Sterility·Sherman J Silber

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