Microdensitometry of T2-weighted magnetic resonance (MR) images from patients with advanced neoplasias in a phase I clinical trial of an infrared pulsed laser device (IPLD)

Lasers in Surgery and Medicine
Luis Santana-BlankKarin E Santana-Rodríguez

Abstract

The aim of this study was to determine whether an infrared pulsed laser device (IPLD)-induced pathophysiologic changes could be identified before measurable modifications in tumor volume. Pre-and post-IPLD treatment magnetic resonance (MR) images of tumor heterogeneities and peritumoral tissues were digitized and a linear transformation was performed to convert images to 256 intensity levels. Data were analyzed by using the Student's t-test and the Kolmogorov-Sminov test (alpha = 0.05). The post-treatment mean intensity values of tumor heterogeneities increased significantly (P < 0.001) for all of the seven patients (n = 7) evaluated. For peritumoral tissues, a significant increase (P < 0.001) was measured in four patients (n = 4). The Kolmogorov-Sminov test showed significant values for the tumor tissue of six (n = 6) patients. This is the first study of early evidence of anti-cancer activity of a novel IPLD showing a significant increase in the water content of tumor heterogeneities before measurable changes in tumor volume.

References

May 1, 1985·Investigative Radiology·S H Koenig, R D Brown
Jan 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigR Ugolini
Feb 7, 1997·Science·J K GregoryR J Saykally
Dec 29, 2000·Lasers in Surgery and Medicine·Y MaegawaM Nishi
Mar 17, 2001·Science·M F Kropman, H J Bakker
Mar 17, 2001·Science·P L GeisslerM Parrinello
Apr 20, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Z HuachouA Nagano
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Aug 30, 2001·Cell·F GalbiatiM P Lisanti
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·F N Keutsch, R J Saykally
Feb 22, 2002·Lasers in Surgery and Medicine·Luis A Santana-BlankKarin E Santana-Rodríguez
Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B D RossA Rehemtulla
Feb 22, 2003·European Journal of Radiology·Andreas M HernethMark Bednarski
Jul 19, 2003·Science·Anne Willem OmtaHuib J Bakker
Aug 2, 2003·The British Journal of Radiology·M JeffreysD Gunnell
Sep 2, 2003·Lasers in Surgery and Medicine·Elizabeth Rodríguez-SantanaDaniel Ortega

❮ Previous
Next ❯

Citations

Sep 8, 2005·Photomedicine and Laser Surgery·Luis A Santana-BlankKarin E Santana-Rodríguez
Jul 24, 2010·Photomedicine and Laser Surgery·Luis Santana-BlankKarin Santana-Rodríguez
Jul 30, 2010·Photomedicine and Laser Surgery·Luis Santana-Blank, Elizabeth Rodríguez-Santana
Mar 21, 2012·Photomedicine and Laser Surgery·Luis Santana-BlankKarin E Santana-Rodríguez
Oct 12, 2012·Photomedicine and Laser Surgery·Luis Santana-BlankKarin E Santana Rodríguez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.