Microdialysis analysis of norepinephrine levels in the paraventricular nucleus in association with food intake at dark onset

Brain Research
X PaezS F Leibowitz

Abstract

It has been proposed that norepinephrine (NE) in the paraventricular nucleus (PVN) acts to stimulate carbohydrate feeding specifically at the start of the active (dark) cycle in rats. This study used microdialysis to examine the relationship between endogenous levels of NE in the PVN at dark onset and the amount of food consumed at this time. The results indicated that: (1) in satiated rats on a lab chow diet, NE levels in the PVN, as opposed to sites anterior or lateral to this nucleus, were significantly higher during large meals around dark onset then they were during small meals or during intervals that preceded the large meals, and (2) in food-deprived animals given a pure carbohydrate diet at dark onset, PVN levels of NE just before the initiation of the meal were significantly higher in animals that consumed a relatively large carbohydrate meal (> 2.0 g) during the first dark hour, and they were significantly correlated across animals with the size of their carbohydrate meal. These findings are consistent with other evidence linking endogenous PVN NE to food intake at the beginning of the natural feeding cycle.

References

Feb 1, 1978·Pharmacology, Biochemistry, and Behavior·S F Leibowitz
Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·J van der Gugten, J L Slangen
Dec 29, 1986·Life Sciences·L HernandezB G Hoebel
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Citations

Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·A MorienJ Fojt
Oct 1, 1995·Behavioural Brain Research·B H Westerink
Nov 10, 1998·Biological Psychiatry·S F Leibowitz, J T Alexander
Oct 31, 2000·Nutrition·P J Wellman
May 10, 2011·Physiology & Behavior·Luis HernándezPedro Rada
Oct 10, 2006·Brain Research Bulletin·N T Bello, A Hajnal
Jul 22, 2008·British Journal of Pharmacology·A A ScopinhoF M A Corrêa
May 29, 2014·British Journal of Pharmacology·M A van GestelS K Janhunen
Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·R K StøvingC Hagen
Feb 2, 2002·The Journal of Nutrition·Carolyn E HuntingtonJ Lee Beverly
May 12, 1998·The American Journal of Physiology·K R HwangJ Y Chan

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