PMID: 11923583Mar 30, 2002Paper

Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol

Alcoholism, Clinical and Experimental Research
Roberto I MelendezJames M Murphy

Abstract

The present study was designed to test directly whether a contextual stimulus for access to ethanol would acquire the ability to enhance locomotor activity and dopamine efflux in the nucleus accumbens (NAc) of alcohol-preferring (P) rats. The study also explored the association between elevated locomotor activity and NAc dopamine efflux during operant self-administration of ethanol. Adult female P rats were randomly assigned to operantly self-administer either 15% (v/v) ethanol or 0.0125% (w/v) saccharin. Both groups were trained in a daily 30-min two-lever concurrent operant task (FR-3) to orally self-administer ethanol or saccharin, with water on the alternate lever. A third (control) group was trained to self-administer water on both levers. All groups were also acclimated in the operant chambers to periods of habituation, anticipation, and postadministration. Compared with controls, the ethanol group, but not the saccharin group, showed significant increases in locomotor activity as well as increased NAc dopamine efflux during the first 10 min of the anticipation period. During the first 10 min of the self-administration period, locomotor activity was significantly increased in both the ethanol and saccharin groups compared...Continue Reading

References

Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·A O Pfeffer, H H Samson
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Mar 14, 1997·Science·W SchultzP R Montague
Jan 23, 1998·Alcoholism, Clinical and Experimental Research·L Williams-Hemby, L J Porrino
Sep 3, 1998·Alcoholism, Clinical and Experimental Research·D L McKinzieT K Li
Oct 13, 1998·Psychopharmacology·R R KohlW J McBride
May 14, 1999·Current Opinion in Neurobiology·P W Kalivas, M Nakamura

❮ Previous
Next ❯

Citations

Jan 2, 2007·Neurotoxicity Research·John H KrystalGodfrey Pearlson
Jan 17, 2007·Psychopharmacology·Karen K SzumlinskiM Scott Bowers
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jodi M GilmanDaniel W Hommer
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David Weinshenker, Jason P Schroeder
Jun 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiTod E Kippin
Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas L KashDanny G Winder
Jun 24, 2010·Journal of Clinical Psychopharmacology·Hugh MyrickRaymond F Anton
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
May 6, 2009·Addiction Biology·Lutske Tampier, Maria Elena Quintanilla
Feb 13, 2010·Addiction Biology·John C CrabbeCindy L Ehlers
Jun 1, 2012·Obesity Facts·Rahul PanditRoger A H Adan
Aug 2, 2007·PloS One·Magalie LenoirSerge H Ahmed
Apr 1, 2014·PloS One·Stephen M TopperJonathan T Pierce-Shimomura
Feb 28, 2014·CNS Drugs·Carolina L Haass-KofflerGeorge A Kenna
Dec 1, 2006·Psychopharmacology·Annemoon M M van Erp, Klaus A Miczek
Aug 21, 2008·Pharmacology, Biochemistry, and Behavior·Richard L BellJames M Murphy
May 30, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brandon M Fritz, Stephen L Boehm
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Susan BarronLinda P Spear
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·William M DoyonRueben A Gonzales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.