PMID: 9176023May 1, 1997Paper

Microdialysis of human breast tissue during the menstrual cycle

Clinical Science
C DabrosinM Hammar

Abstract

1. Previously it has been impossible to perform studies of human breast tissue in vivo. In this study, we investigated whether the microdialysis technique is applicable in human breast tissue and whether the concentrations of amino acids, lactate and pyruvate change during the menstrual cycle. 2. Microdialysis was performed twice during the menstrual cycle in eight healthy women, in the breast and subcutaneous fat. Amino acids, lactate and pyruvate were analysed by HPLC. 3. None of the women showed any complications, such as bleeding or infection, after the experiments. The concentrations of aspartic acid, asparagine, serine, glycine, threonine, tyrosine and ornithine were decreased in the breast late in the menstrual cycle. In the subcutaneous fat, the concentration of glycine decreased late in the cycle. 4. This study has shown that microdialysis is a safe technique and is suitable for investigations of human breast tissue. Our data indicate that metabolism in the breast changes during the menstrual cycle. The lower levels of specific amino acids late in the menstrual cycle could indicate a higher proliferative and/or apoptotic activity during this period. However, the data we have obtained cannot yet be fully explained.

Citations

Apr 10, 2016·Journal of Mammary Gland Biology and Neoplasia·Vivian MoradCharlotta Dabrosin
Oct 11, 2011·PloS One·Ulrika W Nilsson ÅbergCharlotta Dabrosin
Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nele Plock, Charlotte Kloft
Apr 28, 2004·Breast Cancer Research and Treatment·Charlotta DabrosinKarin Ollinger
Oct 8, 2005·Angiogenesis·Charlotta Dabrosin
Aug 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Annelie AbrahamssonCharlotta Dabrosin
May 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Vivian MoradCharlotta Dabrosin
Jan 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Nina Dabrosin, Charlotta Dabrosin
Jul 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·C Dabrosin
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina Bendrik, Charlotta Dabrosin
Aug 15, 2018·Frontiers in Immunology·Gabriela Vazquez RodriguezCharlotta Dabrosin
Aug 12, 2003·Breast Cancer Research and Treatment·Charlotta Dabrosin
Mar 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karin Söderlund LeiflerCharlotta Dabrosin
Nov 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Sofija Mijic, Charlotta Dabrosin
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ulrika W NilssonCharlotta Dabrosin
Apr 23, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susanne SvenssonCharlotta Dabrosin
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charlotta Dabrosin

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