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Microdialysis study of the effects of the antiparkinsonian drug budipine on L-DOPA-induced release of dopamine and 5-hydroxytryptamine by rat substantia nigra and corpus striatum

Synapse

Aug 25, 1999

C S Biggs, M S Starr

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PubMed

Abstract

The purpose of this study was to determine if systemic treatment with the antiparkinsonian drug budipine was capable of influencing the release of dopamine newly synthesised from L-DOPA in the substantia nigra and corpus striatum of the monoamine-depleted rat. Dual probe microdialysis w...read more

Mentioned in this Paper

Demser
Adrenergic Uptake Inhibitors
Neostriatum
Extracellular
Entire Corpus Striatum
Serotonin
Congenital Abnormal Synostosis
Lentiform Nucleus Structure
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Substantia Nigra Structure
Paper Details
References
  • References26
  • Citations6
123
  • References26
  • Citations6
1

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Microdialysis study of the effects of the antiparkinsonian drug budipine on L-DOPA-induced release of dopamine and 5-hydroxytryptamine by rat substantia nigra and corpus striatum

Synapse

Aug 25, 1999

C S Biggs, M S Starr

PMID: 10459170

DOI: 10.1002/(sici)1098-2396(199910)34:1<36::aid-syn5>3.0.co;2-g

Abstract

The purpose of this study was to determine if systemic treatment with the antiparkinsonian drug budipine was capable of influencing the release of dopamine newly synthesised from L-DOPA in the substantia nigra and corpus striatum of the monoamine-depleted rat. Dual probe microdialysis w...read more

Mentioned in this Paper

Demser
Adrenergic Uptake Inhibitors
Neostriatum
Extracellular
Entire Corpus Striatum
Serotonin
Congenital Abnormal Synostosis
Lentiform Nucleus Structure
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt
Substantia Nigra Structure

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Parkinson's Disease (MDS)

Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

Dopamine & Behavior

Dopamine is a neurotransmitter and a hormone commonly associated with the brain's pleasure and reward system. Here is the latest research on its role in affecting and guiding human behaviour.

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Paper Details
References
  • References26
  • Citations6
123
  • References26
  • Citations6
1

Download from

Publisher
PubMed
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